Hot Topic Commentary

• R0 Liver Resection should be a First-line Treatment for Selected Patients with Intermediate Hepatocellular Cancer   

  Martin Janicko, Sylvia Drazilova, Peter Jarcuska

  

Letter to the Editor

• Metabolic Phenotypes: Drivers of Health Outcomes in Fatty Liver Diseases   

  Phunchai Charatcharoenwitthaya

  

Original Article

• Akkermansia muciniphila and Bifidobacterium bifidum Prevent NAFLD by Regulating FXR Expression and Gut Microbiota

  Fulin Nian, Longyun Wu, Qiaoyun Xia, Peiying Tian, Chunmei Ding, Xiaolan Lu

  
• Comparison of Clinical Characteristics and Outcomes of MAFLD and NAFLD in Chinese Health Examination Populations

  Xin Xu, Xiaohua Zhou, Ting Tian, Yuqing Ding, Chengxiao Yu, Wei Zhao, Xiao Wang, Jing Lu, Wen Guo, Longfeng Jiang, Quanrongzi Wang, Qun Zhang, Ci Song

  

• IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis

  Lichao Yao, Xue Hu, Mengqin Yuan, Qiuling Zhang, Pingji Liu, Lian Yang, Kai Dai, Yingan Jiang

  
• Performance of the Enhanced Liver Fibrosis Score, Comparison with Vibration-controlled Transient Elastography Data, and Development of a Simple Algorithm to Predict Significant Liver Fibrosis in a Community-based Liver Service: A Retrospective Evaluation

  Tina Reinson, Janisha Patel, Mead Mathews, Derek Fountain, Ryan M. Buchanan, Christopher D. Byrne

  
• Portal Fibrotic Cord is Associated with Transjugular Intrahepatic Portosystemic Shunt Failure and Death in Cirrhotic Patients

  Yunshu Yang, Chuangye He, Xulong Yuan, Kai Li, Wenyuan Jia, Jing Niu, Na Han, Jiao Xu, Ying Zhu, Li Xu, Yuxuan Mao, Yuanping Xu, Xiaoyuan Gou, Jun Tie

  

• Liver Stiffness Measurement can Predict Liver Inflammation in Chronic Hepatitis B Patients with Normal Alanine Transaminase

  Ling-Ling Huang, Xue-Ping Yu, Qing-Fa Ruan, Yan-Xue Lin, Huan Li, Wen Jin, Rui-Feng Liu, Yan-Lan Liang, Yu-Rui Liu, Yue-Yong Zhu, Jia-Ji Jiang, Ri-Cheng Mao, Da-Wu Zeng

  
• Vaginal Delivery and Breastfeeding Benefit Infant Immune Response to Hepatitis B Vaccine: A Prospective Cohort Study

  Huiqing Liu, Lili Li, Yali Li, Minmin Liu, Yarong Song, Feng Ding, Xiaoshu Zhang, Jie Li

  
• Double Plasma Molecular Adsorption System with Sequential Low-dose Plasma Exchange in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure: A Prospective Study

  Lu Wang, Wenxiong Xu, Shu Zhu, Guoli Lin, Jing Lai, Yufeng Zhang, Ying Liu, Lihua Zheng, Qiumin Luo, Zhiliang Gao, Chan Xie, Liang Peng

  
• IL2-inducible T-cell Kinase is Required for HBV-induced Type T Interferon Expression and Antiviral Response

  Mengxin Lin, Ruyi Guo, Dawu Zeng, Jiangfu Liu, Minghui Zheng, Zhijun Su

  

• Stratified Analysis of Survival Benefit for ABO-incompatible Deceased-donor Liver Transplantation: Multicenter Propensity Score-matched Study

  Mengfan Yang, Xuyong Wei, Abdul Rehman Khan, Qiang Wei, Rui Wang, Binhua Pan, Kun Wang, Zhisheng Zhou, Di Lu, Beini Cen, Shuijun Zhang, Wenzhi Guo, Shusen Zheng, Yang Yang, Xiao Xu

  
• Randomized Trial of Ciclosporin with 2-h Monitoring vs. Tacrolimus with Trough Monitoring in Liver Transplantation: DELTA Study

  Bastian N. Ruijter, Akin Inderson, Aad P. van den Berg, Herold J. Metselaar, Jeroen Dubbeld, Maarten E. Tushuizen, Robert J. Porte, Wojciech Polak, Danny van der Helm, Marjolein van Reeven, Mar Rodriguez-Girondo, Bart van Hoek

  

• Single-cell RNA-seq Revealed that Altered Tumor Infiltrating Lymphocytes in Cirrhotic Liver Indicate Development of Hepatocellular Carcinoma

  Jingxian Duan, Peng Zhu, Yong Zhang, Tianhao Mu, Yingqiang Li, Rui Xiong, Su Chen, Yingmei Li, Zhicheng Li, Shifu Chen, Lei Zhang

  
• Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma

  Zhitao Jiang, Liyuan Gao, Chundi Liu, Jianchun Wang, Yi Han, Jinhuo Pan

  
• Aminoacyl-tRNA Synthetase-based Prognosis Model and Exploration of Potential Mechanisms in Hepatocellular Carcinoma

  Yixun Jin, Xinyang Huang, Zhuoxin Wang, Hui Xu, Qi Wang, Lifu Wang

  
• Diagnostic Efficacy and Possible Underlying Mechanisms of Noninvasive Clinical Markers in Hepatocellular Carcinoma

  Chao-Xu Fu, Jun Li, Zheng-Da Chen, Yan-Ping Cao, Hong-Ling Zhang, Hong-Ting Sui, Bao-Cheng Shan, Lei Xu, Yang Zhou, Min Zhou, En-Yue Yang, Hong-Xin Piao

  

Review Article

• Primary Non-HFE Hemochromatosis: A Review   

  Alla Turshudzhyan, David C. Wu, George Y. Wu

  
• Secondary Iron Overload and the Liver: A Comprehensive Review   

  Kanokwan Pinyopornpanish, Adisak Tantiworawit, Apinya Leerapun, Atiwat Soontornpun, Satawat Thongsawat

  
• Primary Hepatic Extra-gastrointestinal Stromal Tumors: Molecular Pathogenesis, Immunohistopathology, and Treatment   

  Erica C. Becker, Gonca Ozcan, George Y. Wu

  
• Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis   

  Abigail Medford, Jonathan Childs, Ashleigh Little, Sanjukta Chakraborty, Leonardo Baiocchi, Gianfranco Alpini, Shannon Glaser

  
• Targeting Gut Microbiota for the Treatment of Primary Biliary Cholangitis: From Bench to Bedside   

  Li Zhang, Ling Yang, Huikuan Chu

  
• Strategies to Prevent Mother-to-child Transmission of Hepatitis B Virus   

  Palittiya Sintusek, Nasamon Wanlapakorn, Yong Poovorawan

  
• Cardiac Syndromes in Liver Disease: A Clinical Conundrum   

  Milos Brankovic, Paul Lee, Nikolaos Pyrsopoulos, Mark Klapholz

  

Illuminating and Instructive Clinical Case

• Portal Hypertension Refractory Ascites Caused by Secondary Hemochromatosis   

  Jun Tie, Wen Yuan Jia, Xiaoyuan Gou

  
• Synchronous Double Primary Combined Hepatocellular-cholangiocarcinoma and Cholangiolocarcinoma in a Cirrhotic Liver   

  Masahiro Sakata, Koji Kitada, Rika Omote, Hiroshi Sonobe, Masashi Utsumi, Naoyuki Tokunaga, Takashi Fushimi, Ryota Nagao, Tatsuro Sakata, Toshihiko Kaneyoshi, Tatsuya Toyokawa, Masaru Inagaki

  

Research Letter

• TDF Promotes Glycolysis and Mitochondrial Dysfunction to Accelerate Lactate Accumulation by Downregulating PGC1α in Mice   

  Yuxuan Luo, Zhiwei Chen, Zhao Li, Aoran Luo, Yi Zeng, Min Chen, Mingli Peng, Hong Ren, Peng Hu