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Impact of patatin-like phospholipase domain-containing-3 rs738409 polymorphism in chronic liver disease: a meta-analysis of 27,365 subjects

  • Yang Zheng1,
  • Lei Wang1,
  • Jia-Hui Wang1,
  • Tian-Jian Liang1,* and
  • Tie-Jian Zhao2,*
Gastroenterology & Hepatology Research   2020;2(4):119-124

doi: 10.53388/ghr2020-12-025

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Citation: Zheng Y, Wang L, Wang JH, Liang TJ, Zhao TJ. Impact of patatin-like phospholipase domain-containing-3 rs738409 polymorphism in chronic liver disease: a meta-analysis of 27,365 subjects. Gastroenterol & Hepatol Res. 2020;2(4):119-124. doi: 10.53388/ghr2020-12-025.

Abstract

Background

Some genetic association studies have investigated the potential role of patatin-like phospholipase domain-containing-3 (PNPLA3) polymorphisms in chronic liver disease, retrieving inconsistent results. Therefore, we performed a meta-analysis to further explore PNPLA3 rs738409 in a large pooled population with chronic liver disease.

Methods

Eligible studies were selected from PubMed, Embase, and CNKI databases. Studies heterogeneity was assessed using I2 statistics: when I2 >50% the random effects model was used to pool the data; otherwise, a fixed effects model was used.

Results

In total, 36 studies were selected, comprising 14,855 cases and 12,510 controls. The analysis showed that rs738409 was significantly associated with chronic liver disease in the general population (dominant model: P < 0.0001, OR=1.62, 95% CI=1.43–1.83, I2=81.2%; recessive model: p<0.0001, OR=2.01, 95% CI=1.75–2.30, I2=74.1%; allele model: P=0.001, OR=1.53, 95% CI=1.39–1.68, I2=84.8%). These significant correlations were further confirmed in Asian and Caucasian populations. A stratified analysis also showed a positive correlation between rs738409 and hepatocellular carcinoma (HCC), cirrhosis, and non-alcoholic fatty liver disease (NAFLD), but not with chronic hepatitis B infection or alcoholic liver disease.

Conclusions

Altogether, PNPLA3 rs738409 may help identify individuals at higher susceptibility to chronic liver disease, in particular for HCC, cirrhosis, and NAFLD.

Keywords

chronic liver disease, meta-analysis, rs738409, single nucleotide polymorphism, patatin-like phospholipase domain-containing-3, PNPLA3

Copyright © 2025 Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zheng Y, Wang L, Wang JH, Liang TJ, Zhao TJ. Impact of patatin-like phospholipase domain-containing-3 rs738409 polymorphism in chronic liver disease: a meta-analysis of 27,365 subjects. Gastroenterol & Hepatol Res. 2020;2(4):119-124. doi: 10.53388/ghr2020-12-025.
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Article History
Received Revised Accepted Published
December 12, 2020
DOI http://dx.doi.org/10.53388/ghr2020-12-025
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