Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining, network pharmacology and molecular docking technology

doi:10.53388/ghr2023-03-079

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Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining, network pharmacology and molecular docking technology

Rui-Zhu Jiang¹,
Yu-Hong Ling¹,
Xin-Rui Xian¹,
Xian-Ling Yuan²,
Yang Zheng¹,
Jia-Hui Wang¹ and
Tie-Jian Zhao^2,*

Gastroenterology & Hepatology Research 2023;5(3):15-15

doi: 10.53388/ghr2023-03-079

Published online: September 25, 2023

Author information

Citation: Jiang RZ, Ling YH, Xian XR, Yuan XL, Zheng Y, Wang JH, et al. Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining, network pharmacology and molecular docking technology. Gastroenterol & Hepatol Res. 2023;5(3):15-15. doi: 10.53388/ghr2023-03-079.

Abstract

Objective

To study the mechanism of action of Xiayuxue Tang in treating hepatic fibrosis by combining GEO data mining, network pharmacology, and molecular docking technology, and provide new research directions for the treatment of hepatic fibrosis.

Method

Utilizing multiple databases, we aim to identify the relevant targets of various components in Xiayuxue Tang and their associations with hepatic fibrosis. After pinpointing the key targets through interaction analysis, we will construct both the compound-target network and the protein interaction network for Xiayuxue Tang. Conclusively, we will conduct GO and KEGG enrichment analyses on these key targets, followed by molecular docking verification.

Result

Through mining the GEO database, 171 related targets were identified. When combined with other databases, a total of 2,343 hepatic fibrosis-related targets were obtained. Xiayuxue Tang comprises 82 related components, which include 26 active components from rhubarb, 1 from ground beetle worm, 46 from peach kernels, with a total of 314 predicted targets. The GO enrichment analysis revealed 748 biological processes, 32 cellular components, and 73 molecular functions, while the KEGG enrichment analysis identified 222 pathways. Molecular docking verification confirmed that effective compounds can bind stably to key proteins, exhibiting strong binding activity. This underscores the potential efficacy of Xiayuxue Tang in addressing hepatic fibrosis.

Conclusion

Xiayuxue Tang exerts regulatory effects on hepatic fibrosis through different targets and pathways, suggesting that the herbal compound has the characteristics of multiple pathways and targets.

Keywords

Xiayuxue Tang, hepatic fibrosis, network pharmacology, molecular docking technology

Copyright © 2025 Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jiang RZ, Ling YH, Xian XR, Yuan XL, Zheng Y, Wang JH, et al. Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining, network pharmacology and molecular docking technology. Gastroenterol & Hepatol Res. 2023;5(3):15-15. doi: 10.53388/ghr2023-03-079.

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Received	Revised	Accepted	Published
			September 25, 2023

DOI http://dx.doi.org/10.53388/ghr2023-03-079

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