Xia & He Publishing

Original Article

Metabolic Liver Diseases

Bidirectional Regulation between Metabolic Dysfunction-associated Steatotic Liver Disease and Sarcopenia via Liver-muscle Crosstalk

Yeyu Song, Yameng Liu, Jie Jiang, Youjie Zheng, Zixuan Wang, Cen Xie, Jian-Gao Fan

Published online: January 7, 2026

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J Clin Transl Hepatol. 2026;14(2):121-136. doi:10.14218/JCTH.2025.00538

Metabolic Risk Factors and Clinical Presentations of Metabolic Dysfunction-associated Steatotic Liver Disease Using Data from the All of Us Research Program

Ke-Qin Hu, Seyedeh Neelufar Payrovnaziri, Argyrios Ziogas, Steven Hiek, Kuangda Shan, Tevan Luong, Jenny Fang, Hoda Anton-Culver

Published online: January 27, 2026

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J Clin Transl Hepatol. 2026;14(2):137-145. doi:10.14218/JCTH.2025.00393

Infectious Hepatitis

Eight-year Results from Two Randomized Phase 3 Trials of Tenofovir Alafenamide for Chronic Hepatitis B Virus Infection in China

Jinlin Hou, Qin Ning, Zhongping Duan, Yu Chen, Qing Xie, Lunli Zhang, Shanming Wu, Hong Tang, Jun Li, Feng Lin, Yongfeng Yang, Guozhong Gong, Yanwen Luo, Yan Chen, Frida Abramov, Leland J. Yee, Hongyuan Wang, Roberto Mateo, Tahmineh Yazdi, Irina Botros, Chengwei Chen, Yan Huang, Mingxiang Zhang, Jidong Jia

Published online: February 4, 2026

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J Clin Transl Hepatol. 2026;14(2):146-158. doi:10.14218/JCTH.2025.00438

Traditional and Novel Virologic Markers for Functional Cure and HBeAg Loss with Pegylated Interferon in Chronic Hepatitis B: A Systematic Review and Meta-analysis

Ying Zhang, Long-Fei Wang, Jing Chen, Mindie H. Nguyen, Qi Zheng

Published online: December 26, 2025

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J Clin Transl Hepatol. 2026;14(2):159-167. doi:10.14218/JCTH.2025.00443

Hepatic and Biliary Neoplasia

Prognostic Nutritional Index Predicts Outcomes in Hepatocellular Carcinoma Treated with Atezolizumab and Bevacizumab: A Propensity Score-matched Analysis

Yuan-Hung Kuo, Wei Teng, Yen-Hao Chen, Po-Ting Lin, Tsung-Han Wu, Chung-Wei Su, Wei-Ting Chen, Chen-Chun Lin, Chao-Hung Hung, Sheng-Nan Lu, Shi-Ming Lin, Jing-Houng Wang, Chun-Yen Lin

Published online: December 8, 2025

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J Clin Transl Hepatol. 2026;14(2):168-176. doi:10.14218/JCTH.2025.00418

Liver Transplantation and Surgery

Serum miR-381-3p: Diagnostic Role and Mechanisms in Liver Transplant Ischemia-reperfusion Injury

Xiaobin Chi, Zerun Lin, Zhijian Chen, Jianda Yu, Yongbiao Chen, Honghuan Lin, Qiucheng Cai, Lizhi Lv

Published online: February 5, 2026

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J Clin Transl Hepatol. 2026;14(2):177-186. doi:10.14218/JCTH.2025.00571

Liver Failure, Cirrhosis and Portal Hypertension

Cathepsin K Alleviates Liver Fibrosis by Inhibiting the TGF-β/Smad Signaling Pathway and Inducing Hepatic Stellate Cell Apoptosis

Zhandong Lin, Yue Shi, Mengjiao Sun, Jiawei Cui, Dandan Zhao, Yaoyao Mao, Congyue Zhang, Ying Zhang, Qianqian Zheng, Yukai Chen, Shaoya Li, Yuemin Nan

Published online: January 22, 2026

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J Clin Transl Hepatol. 2026;14(2):187-201. doi:10.14218/JCTH.2025.00592

Review Article

Tumor Vaccines in Hepatocellular Carcinoma: Advances, Challenges, and the Path Toward Precision Immunotherapy

Bin Niu, Jun Xu, Liaoyun Zhang

Published online: January 19, 2026

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J Clin Transl Hepatol. 2026;14(2):202-214. doi:10.14218/JCTH.2025.00401

Risk Factors and Biomarkers for Immune Checkpoint Inhibitor-mediated Hepatotoxicity: Emerging Insights and Future Perspectives

Zaoqin Yu, Yanjiao Xu, Wei Li, Yingjie Hu, Chengliang Zhang

Published online: January 23, 2026

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J Clin Transl Hepatol. 2026;14(2):215-231. doi:10.14218/JCTH.2025.00622

Repurposing SGLT2 Inhibitors for Cirrhotic Ascites: From Mechanistic Research to Clinical Exploration

Yuan Gao, Yunyi Gao, Dong Ji, Zhongjie Hu