Original Article

ATOX1 Promotes Hepatocellular Carcinoma Carcinogenesis via Activation of the c-Myb/PI3K/AKT Signaling Pathway Qin Ouyang, Siyu Jia, Qianyu Zhu, Yanmeng Li, Huaduan Zi, Sisi Chen, Pingping He, Hengcheng Tang, Yanling Li, Anjian Xu, Bei Zhang, Xiaomin Wang, Xiaojuan Ou, Donghu Zhou, Jian Huang Published online: July 7, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00422

CCNE1 Promotes the Progression of Hepatic Precancerous Lesion and the Malignant Phenotype of Hepatocellular Carcinoma Kai Zhang, Xue Hu, Lichao Yao, Wenzhi Guo Published online: April 28, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00428

Cumulative Hepatitis B Surface Antigen/Hepatitis B Virus DNA Ratio in Immune-tolerant Hepatitis B Patients: A 10-year Follow-up Study Dawu Zeng, Yanfang Huang, Sheng Lin, Naling Kang, Yanxue Lin, Jiaji Jiang, Yueyong Zhu, Qi Zheng, Jiming Zhang Published online: July 4, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00205

Interim Analysis of 48-week Tenofovir Amibufenamide Treatment in Chronic Hepatitis B Patients with Normal Alanine Aminotransferase Levels: The PROMOTE Study Honglian Gui, Yingqiu Shen, Lin Tan, Piao Hu, Feng Qian, Xiaoping Wu, Yuanwang Qiu, Sujun Zheng, Jiaojian Lv, Yunzhen Shi, Jun Li, Yongfang Jiang, Zhizhen Hu, Fanru Nie, Yan Huo, Lihong Qu, Qing Xie Published online: June 30, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00162

Global Trends and Cross-country Inequalities of Acute Hepatitis E in the Elderly, 1990–2021: A Comprehensive Analysis Deliang Huang, Jinyan Jiang, Jinghan Peng, Zhibin Zhu, Yuanyuan Chen, Siyu Zhang, Huiyi Lai, Hong Yu, Qi Zhao, Yanna Wu, Yanping Chen, Jun Chen Published online: May 30, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00101

The Gut Microbiota in Elderly Patients with Acute Hepatitis E Infection Miaomiao Li, Meng Shi, Changyi Ji, Luyu Wang, Ze Xiang, Ying Wang, Hongtao Wang, Mengmeng Gu, Runing Ji, Jian Wu Published online: May 26, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00111

Clinical, Microbiological, and Antibiotic Treatment Characteristics of Bacterial Infections in Patients with Liver Cirrhosis in China: A Multicenter Study Xiuding Zhang, Haoda Weng, Qinzhi Deng, Min Deng, Xuwei Wu, Zuxiong Huang, Shourong Liu, Rui Wu, Chunlian Ma, Yao Xu, Jianfeng Zhong, Jie Yang, Yinxia Wu, Huajiang Shen, Feng Ding, Fang Wang, Xuezhen Zhai, Chunxian Peng, Haotang Ren, Jie Jin, Xiangfei Xu, Xiaofei Li, Xiaoting Ye, Guoqing Qian, Shuilin Sun, Xuebing Yao, Haifeng Miao, Qianggu Xiao, Shaoheng Ye, Qing Zhang, Xinyi Xu, Xia Yu, Yue Yu, Yan Lan, Huilan Tu, Xianbin Xu, Xinrong Zhang, Rui Huang, Xiaohan Qian, Qiao Yang, Jifang Sheng, Yu Shi Published online: July 3, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00211

Adrenomedullin as an Immunomodulator of CD14+MerTK+ Circulating Monocytes in Liver Failure Syndromes Francesca Maria Trovato, Florent Artru, Roosey Sheth, Rima Abdalla, Joseph Wilson, Anna Broderick, John Smith, Stephen Atkinson, Mark J. McPhail Published online: June 24, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00074

Integrated Analysis of Serum and Fecal Metabolites Reveals the Role of Bile Acid Metabolism in Drug-induced Liver Injury: Implications for Diagnostic and Prognostic Biomarkers Simiao Yu, Sici Wang, Ping Li, Haocheng Zheng, Jing Jing, Tingting He, Xia Ding, Ruilin Wang Published online: June 30, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00073

Assessment of Metabolic Dysfunction-associated Steatotic Liver Disease and Liver Fibrosis: A Cross-sectional Study in Asymptomatic Individuals in Greater Vancouver Nicholas W. Tjandra, David M.P. Di Fonzo, Tianyi Wen, Kirby Lau, Peter Kwan, Eric M. Yoshida, Daljeet Chahal Published online: June 23, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00109

Short-term Physical Activity Reduces Metabolic-associated Steatohepatitis by Promoting the Degradation of Branched-chain Amino Acids in Skeletal Muscle Mingshu Gao, Jiaying Li, Yanan Zhang, Jiangtao Huang, Jiaqi Chen, Dawen Liao, Shengnan He, Qian Bi, Lele Ji, Yulu Du Published online: May 30, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00072

Review Article

Orphan Nuclear Receptors in Metabolic Dysfunction-associated Steatotic Liver Disease Development Huan Li, Jian Chen, Ziyin Huang, Mingkai Chen Published online: June 19, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00019

Epidemiology, Achievements, and Challenges in the Elimination of Hepatitis B in China You Deng, Tongtong Meng, Hong You, Jidong Jia, Yu Wang Published online: May 21, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00039

Research Letter

Development and Validation of a Novel Noninvasive Model to Predict Liver Fibrosis Staging in Untreated Patients with Chronic Hepatitis B Jianhua Hu, Xiaoli Zhang, Zhibo Zhou, Fangfang Geng, Hongyu Jia, Linfeng Jin, Weixiang Zhong, Guodong Yu, Xue Wen, Hainv Gao, Yida Yang Published online: July 7, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00175

Complete Resolution of Refractory Ascites and Pleural Effusion with Sustained Improvement in Urinary Sodium Excretion in a Cirrhotic Patient Treated with Empagliflozin Wei Qin, Yunyi Gao, Yuanyuan Zhao, Ning Bian, Weiguang Fan, Wei Wang, Yuan Gao, Zhongjie Hu Published online: June 19, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00172

Characteristics of a Chinese Cohort of Patients with Chronic Hepatitis C Infection (2019–2023) and a Case Report of Resistance-associated Substitutions to Sofosbuvir-velpatasvir Treatment Hao Xiong, Shaokun Pan, Chaohui Zhou, Hong Shi, Youhua Xie, Jinsheng Guo Published online: April 10, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00033

Letter to the Editor

Anti-mitochondrial Antibodies in Patients with Elevated Alkaline Phosphatase/Gamma-glutamyl Transferase Levels: Hallmark or Bystander? Fukui Zhang Published online: June 30, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00168