Editorial

• Unraveling the Dynamic Role of Microtubules in the HBV Life Cycle   

  Urania Georgopoulou, John Koskinas

  

Hot Topic Commentary

• Acute Severe Hepatitis of Unknown Origin in Children Across the World: A 2022 Source of Concern   

  Lampros Chrysavgis, Evangelos Cholongitas

  

Original Article

• PNPLA3 rs738409 C>G Variant Influences the Association Between Visceral Fat and Significant Fibrosis in Biopsy-proven Nonalcoholic Fatty Liver Disease

  Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Ou-Yang Huang, Rafael S. Rios, Kenneth I. Zheng, Sui-Dan Chen, Hong-Lei Ma, Giovanni Targher, Christopher D. Byrne, Xiao-Yan Pan, Ming-Hua Zheng

  

• Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study

  Qiqi Zhang, Hui Huang, Aijun Sun, Chunyan Liu, Zhidong Wang, Feifan Shi, Wei Duan, Xueying Sun, Qi Wang, Ping Sun, Chunwen Pu, Yong Zhang

  
• Clinical Predictors of Functional Cure in Children 1–6 Years-old with Chronic Hepatitis B

  Jing Pan, Haiyan Wang, Tiantian Yao, Xuejiao Liao, Hao Cheng, Suthat Liangpunsakul, Yan Wang, Min Zhang, Zheng Zhang

  
• Impact of National Centralized Drug Procurement Policy on Antiviral Utilization and Expenditure for Hepatitis B in China

  Xinyu Zhao, Min Li, Hao Wang, Xiaoqian Xu, Xiaoning Wu, Yameng Sun, Canjian Ning, Bingqiong Wang, Shuyan Chen, Hong You, Jidong Jia, Yuanyuan Kong

  
• Hepatitis B Virus Induces Microtubule Stabilization to Promote Productive Infection through Upregulating Microtubule-associated Protein 1S

  Yuanyue Guan, Bin Sun, Shijie Zhang, Yuan Zhuang, Yanxiang Huang, Minghua Lin, Rongling Zheng, Dexi Chen, Ying Shi, Yanjun Wang

  

• Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome

  Yimei Liu, Ninghua Liu, Yujing Liu, Hongyu He, Zhe Luo, Wenjun Liu, Nan Song, Minjie Ju

  

• Racial and Health Disparities among Cirrhosis-related Hospitalizations in the USA

  Ashwani K. Singal, Yong-Fang Kuo, Juan P. Arab, Ramon Bataller

  
• Advantages of a Novel Model for Predicting Hepatic Fibrosis in Chronic Hepatitis B Virus Carriers Compared with APRI and FIB-4 Scores

  Na-Ling Kang, Qing-Fa Ruan, De-Sheng Zhang, Xue-Ping Yu, Zhen-Ting Hu, Zhi-Min Lin, Lu-Ying Wu, Meng-Xin Lin, Zu-Xiong Huang, Jia-Ji Jiang, Yu-Rui Liu, Ri-Cheng Mao, Da-Wu Zeng

  
• Relationship between the Level of Serum Golgi Protein 73 and the Risk of Short-term Death in Patients with ALD-ACLF

  Jingjing Tong, Mingjie Yao, Xiuying Mu, Leijie Wang, Xiajie Wen, Xingran Zhai, Xiang Xu, Yu Wang, Jing Chen, Xiangwei Zhai, Chongdan Guan, Fengmin Lu, Jinhua Hu

  
• Development and Validation of a Nomogram for 90-day Outcome in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure

  Jun Yang, Ran Xue, Jing Wu, Lin Jia, Juan Li, Hongwei Yu, Yueke Zhu, Jinling Dong, Qinghua Meng

  

• Dermcidin Enhances the Migration, Invasion, and Metastasis of Hepatocellular Carcinoma Cells In Vitro and In Vivo

  Fanghua Qiu, Huajing Long, Lu Zhang, Jieyuan Liu, Zetian Yang, Xianzhang Huang

  

Review Article

• Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies   

  Nelia Hernandez, Fernando Bessone

  
• Tumor-associated Exosomes Are Involved in Hepatocellular Carcinoma Tumorigenesis, Diagnosis, and Treatment   

  Hang Wang, Liang Yu, Peng Huang, Yongxu Zhou, Wangyang Zheng, Nanfeng Meng, Risheng He, Yi Xu, Tey Sze Keong, Yunfu Cui

  
• Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?   

  Jing Li, Wei Hu, Ji-Yuan Zhang, Fu-Sheng Wang

  
• Update on Sphincter of Oddi Dysfunction: A Review   

  Jaimy Villavicencio Kim, George Y. Wu

  
• Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak   

  Li-Ya Zhang, Li-Su Huang, Yu-Hang Yue, Rima Fawaz, Joseph K. Lim, Jian-Gao Fan

  
• Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Review   

  Teresa Da Cunha, Haleh Vaziri, George Y. Wu

  
• Statin-induced Liver Injury Patterns: A Clinical Review   

  Leon D. Averbukh, Alla Turshudzhyan, David C. Wu, George Y. Wu

  
• Neoadjuvant and Adjuvant Therapy in Intrahepatic Cholangiocarcinoma   

  Xing Chen, Jinpeng Du, Jiwei Huang, Yong Zeng, Kefei Yuan

  

Case Report

• Imaging Findings of Hepatic Ewing’s Sarcoma on Computed Tomography and Gadobenate Dimeglumine-enhanced Magnetic Resonance Imaging: A Case Report and Literature Review   

  Tao Lu, Wenhao Yang, Xingchao Liu, Xudan Yang, Chong Yang, Wenjia Di