Original Article

• Consensus versus Outcome-based Definitions of Acute-on-chronic Liver Failure: Implications for Risk Stratification and Case Identification

  Nipun Verma, Tingting Qi, Pratibha Garg, Arun Valsan, Gowripriya Nair, Julian Pohl, Arathi Venu, Xianbo Wang, Xin Zheng, Guohong Deng, Yan Huang, Zhongji Meng, Yanhang Gao, Zhiping Qian, Xiaobo Lu, Feng Liu, Yu Shi, Jia Shang, Yubao Zheng, Yingli He, Meiqian Hu, Changze Hong, Sina Jameie-Oskooei, Raj Mookerjee, Mohammad Mahdi Saeidinejad, Sunil Taneja, Jinjun Chen, Hai Li, Ajay Duseja, Cornelius Engelmann, Rajiv Jalan

  
• A Novel Simplified Prognostic Model for 90-day Transplant-free Survival in Patients with Severe Acute Liver Injury/Acute Liver Failure

  Yan Ren, Manman Xu, Wenling Wang, Ming Kong, Yu Chen

  

• A Dual Time Window-driven Strategy to Optimize Primary Biliary Cholangitis Treatment via Alkaline Phosphatase Normalization

  Han Zhao, Yansheng Liu, Yingmei Tang, Ningning Wang, Yanmin Liu, Yiling Li, Chunyang Huang, Jieting Duan, Yan Feng, Linhua Zheng, Ruiqing Sun, Xiufang Wang, Juan Deng, Gui Jia, Patrick S.C. Leung, M. Eric Gershwin, Yulong Shang, Ying Han

  
• Bile Drainage Improves Survival in Amatoxin-induced Severe Liver Injury: A Prospective Pilot Cohort Study

  Xiuying Ma, Bin Han, Wei Yue, Yuan Shen, Jiawei Geng

  
• A Multi-omics and Machine Learning Framework Identifies Plasma SBDS as a Causal Biomarker and Therapeutic Target in Primary Sclerosing Cholangitis

  Pengfei Cheng, Yuanming Qiang, Yibo Sun, Binwei Duan, Yabo Ouyang, Guangming Li

  

• Metabolic Dysfunction-associated Steatotic Liver Disease Diminishes the Efficacy of miR-125b-5p-engineered MSC Therapy for Hepatocellular Carcinoma via HK2 Upregulation: A Multimodal Theranostic Study

  Lishan Shen, Xiaowen Luo, Xiaorui Su, Xiang Zhou, Fengyun Zou, Shuangshuang Zhong, Yayin Deng, Boya Yin, Zhicheng Yao, Ruomi Guo

  

Review Article

• Reducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review

  Nikolaos T. Pyrsopoulos, Nadege Gunn, Prasun K. Jalal, George E. Catinis

  
• Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B

  Siqi Sun, Sisi Yang, Yihe Yu, Jiyang Chen, Jintao Ning, Yida Yang, Hongyu Jia

  
• The Association of Alpha-1 Antitrypsin Deficiency and Arterial Aneurysms: An Update and Review

  Moana Da Silva Santiago, George Y. Wu

  
• The Multifaceted Roles of Gut Microbiota and Their Metabolites in Metabolic Dysfunction-associated Steatotic Liver Disease: A Literature Review

  Yunqi Zhang, Dengqin Wang, Bo Zhuang, Fangzhuo Zhu, Chengwei Tan, Jing Zhang, Qianqian Zhang

  
• Dubin-Johnson and Rotor Syndromes: A Review and Update of Pathophysiological Mechanisms

  Bianca Thakkar, George Y. Wu

  
• Mechanisms and Prognostic Assessment Value of Thyroid Hormone in Liver Failure

  Hong Zhou, Hong Wu, Shao-Hui Su, Shan-Hong Tang

  

Letter to the Editor

• Letter to the Editor: Genotype-specific Response to 144-week Entecavir Therapy for HBeAg-positive Chronic Hepatitis B with a Particular Focus on Histological Improvement: A Prospective Study

  Chenhao Ye, Lei Wang

  

Illuminating and Instructive Clinical Case

• Occlusion of Paraspinal Vein Shunt Alleviated Post-TIPS Hepatic Myelopathy in a Patient with Cirrhosis

  Yuhong Suo, Lixue Xu, Xinyan Zhao, Yu Wang, Fuliang He, Jidong Jia