Original Article

• HBx Facilitates Drug Resistance in Hepatocellular Carcinoma via CD133-regulated Self-renewal of Liver Cancer Stem Cells

  Xiangshu Jin, Huijun Dong, Juan Wang, Guomin Ou, Xinyuan Lai, Xing Tian, Lei Wang, Hui Zhuang, Tong Li, Kuanhui Xiang

  
• Burden of Liver Cancer Attributable to Hepatitis B and Alcohol Globally, in China, and for Five Sociodemographic Index Regions from 1990 to 2021: A Population-based Study

  Xiuxiu Deng, Hui Li, Yuru Zhong, Haibo Wang, Lixin Ke, Zhifei Wang, Alexios-Fotios A. Mentis, Yangqin Xun, Qiang Zhang, Cuncun Lu

  

• ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury

  Mingyan Ji, Yun Chen, Yifan Ma, Dongping Li, Jin Ren, Hongyue Jiang, Sinuo Chen, Xiaoqing Zeng, Hong Gao

  
• Plasma Extracellular Vesicle-derived MicroRNA Associated with Human Alpha-1 Antitrypsin Deficiency-mediated Liver Disease

  Regina Oshins, Zhiguang Huo, Zachary Greenberg, Virginia Clark, Sergio Duarte, Huiping Zhou, Jesse West, Mei He, Mark Brantly, Nazli Khodayari

  

• Risk of Coronary Artery Disease in Patients with Liver Cirrhosis: A Systematic Review and Meta-analysis

  Chunru Gu, Liyan Dong, Lu Chai, Zhenhua Tong, Fangbo Gao, Walter Ageno, 
Fernando Gomes Romeiro, Xingshun Qi

  
• Sodium Butyrate Inhibits Necroptosis by Regulating MLKL via E2F1 in Intestinal Epithelial Cells of Liver Cirrhosis

  Yimeng Zhou, Yang Ding, Yanwei Li, Qiuju Sheng, Chao Han, Yaoxin Fan, Ziyi Wang, Bingchao Lu, Xiaoguang Dou, Chong Zhang

  
• The Imbalance of Homeostasis in Neutrophil Extracellular Traps is Associated with Portal Vein Thrombosis in Patients with Decompensated Cirrhosis

  Ming Han, Yujia Liu, Ying Cao, Yue Zhang, Yonghong Yan, Shuwei Deng, Xiaoxue Yuan, Huichun Xing, Yuan Huang, Liuluan Zhu

  

• Anti-hepatitis B Virus Treatment with Tenofovir Amibufenamide Has No Impact on Blood Lipids: A Real-world, Prospective, 48-week Follow-up Study

  Yue Chen, Wenkang Gao, Huikuan Chu, Afnan Ahmed Mohamed Al-Asbahi, Shengqi Yan, Hang Yuan, Jiake Che, Zilu Cheng, Zexuan Li, Jin Ye, Rong Lin, Xiaohua Hou, Fan Du, Ling Yang

  

• Advanced Liver Fibrosis Predicts Liver Outcomes in Biopsy-proven Metabolic Dysfunction-associated Steatotic Liver Disease: A U.S.-based Single-center Retrospective Cohort Study

  Robert Lam, Dhanpat Jain, Yanhong Deng, Eesha Acharya, Joseph K. Lim

  

Review Article

• Exosome-mediated Crosstalk in the Tumor Immune Microenvironment: Critical Drivers of Hepatocellular Carcinoma Progression

  Yifei Ge, Lixue Jiang, Qingfu Dong, Yi Xu, Judy Wai Ping Yam, Xiangyu Zhong

  
• The Development and Appraisal of MELD 3.0 in Liver Diseases: Good Things Never Come Easy

  Gaoyue Guo, Wanting Yang, Jia Li, Ziyi Yang, Jing Liang, Chao Sun

  
• T-cell Receptor Repertoire Analysis in the Context of Transarterial Chemoembolization Synergy with Systemic Therapy for Hepatocellular Carcinoma

  Jie Li, Yuyuan Zhang, Luqi Hu, Heqing Ye, Xingli Yan, Xin Li, Yifan Li, Shuwen Ye, Bailu Wu, Zhen Li

  
• Current Status of Glucagon-like Peptide-1 Receptor Agonists in Metabolic Dysfunction-associated Steatotic Liver Disease: A Clinical Perspective

  Ming-Wang Wang, Lun-Gen Lu

  
• Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective

  Hartmut Jaeschke, Anup Ramachandran

  
• Emerging Roles of High-mobility Group Box-1 in Liver Disease

  Lu Wang, Zhiwei Dong, Yeqiong Zhang, Liang Peng

  
• Exploring Circulating Tumor Cells: Detection Methods and Biomarkers for Clinical Evaluation in Hepatocellular Carcinoma

  Chin-Mu Hsu, Yi-Chang Liu, Jee-Fu Huang

  

Illuminating and Instructive Clinical Case

• Ferrochelatase Gene Variants Associated with Cholestasis in Adults: A Case Report

  Xiaona Lu, Kun Liu, Wenlan Zheng, Xuemei Zhang, Jia Shi, Shihan Yu, Yueqiu Gao, Hai Feng, Zhuo Yu

  

Research Letter

• Delay in Paracentesis and Clinical Outcomes in Hospitalized Patients with Cirrhosis and Ascites

  Ashwani K. Singal, Yong-Fang Kuo

  
• The Failure Rate of Liver Stiffness Measured by Vibration-controlled Transient Elastography in the United States and Relevant Factors

  Ruoqi Zhou, Jiyang Chen, Rui Huang, Yida Yang, Yu Shi

  

Hot Topic Commentary

• Prolonged Direct Hyperbilirubinemia Following Acute Hepatitis: When Not to Worry?

  Danzhu Zhao, George Y. Wu