场景1：补实验（能做）

补充相应的实验结果，将补充的数据加入到文稿相应位置。有必要的话，还需要在讨论部分进行讨论。

We appreciate the reviewer's suggestion to assess the level of XX. Following this recommendation, we performed ELISA assays (n=6). As presented in Figure 3C, the results align with our hypothesis and provide additional support for the involvement of the XX mechanism. The corresponding description can be found on page 7, lines 12–18.

场景2：补实验（做不到）

如果确实没有办法补充相关实验，可以考虑检索相关文献，看是否能够给出一些解释。

Thank you for your comment regarding the validation of the XX mechanism.

Current research has confirmed that XX is a key regulator of the XX pathway (references). We have already discussed this point in the Discussion section. (Page 15, lines 287–296)

如果相关文献不能解释，可以将这一点作为局限性写在文章中，并表明接下来会对这一内容进行研究。

Thank you for your suggestion to validate XX using single-cell sequencing. Due to constraints in funding and project timeline, we are currently unable to carry out this experiment. However, we have acknowledged this limitation in the “Limitations” section and highlighted the idea as an important direction for future research (Page 15, lines 323–325)

场景3：创新性不足

修改相关阐述并突出自己的创新方面。

Thank you for your comments. We have thoroughly revised both the Introduction and Discussion sections to better highlight two key innovative aspects of our study: 1) the novel application of Method A to Field B, and 2) the discovery of a direct link between Phenomenon C and Pathway D (Page 2, Lines 8-15; Page 12, Lines 216-218). We hope that the revised manuscript now more clearly presents the unique contributions of our research.

场景4：格式/语法/拼写错误

有些期刊会因为是中国人，常规质疑语言问题。不用担心，可以找专业结构来帮助修改语言，并提供语言证明。

We deeply apologize for the persistent grammatical and stylistic issues. All specific issues you raised were meticulously corrected. We have also engaged a native English-speaking medical editor from Medjaden Inc., a professional editing company, who has expertise in XX to perform a comprehensive, line-by-line language edit of the entire manuscript. Upon resubmission, we provide the official certificate of English language editing from the service as proof of this professional intervention.