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Publications > Journals > Journal of Clinical and Translational Hepatology > Article Full Text

  • Review Article
  • OPEN ACCESS

Efficacy of Vaccine Protection Against COVID-19 Virus Infection in Patients with Chronic Liver Diseases

  • Carmen Ka Man Cheung1 ,
  • Kimmy Wan Tung Law2 ,
  • Alvin Wing Hin Law2 ,
  • Man Fai Law1,* ,
  • Rita Ho3  and
  • Sunny Hei Wong4 
 Author information
Journal of Clinical and Translational Hepatology   2023;11(3):718-735

doi: 10.14218/JCTH.2022.00339

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Vaccination against coronavirus disease 2019 is a useful weapon to combat the virus. Patients with chronic liver diseases (CLDs), including compensated or decompensated liver cirrhosis and noncirrhotic diseases, have a decreased immunologic response to coronavirus disease 2019 vaccines. At the same time, they have increased mortality if infected. Current data show a reduction in mortality when patients with chronic liver diseases are vaccinated. A suboptimal vaccine response has been observed in liver transplant recipients, especially those receiving immunosuppressive therapy, so an early booster dose is recommended to achieve a better protective effect. Currently, there are no clinical data comparing the protective efficacy of different vaccines in patients with chronic liver diseases. Patient preference, availability of the vaccine in the country or area, and adverse effect profiles are factors to consider when choosing a vaccine. There have been reports of immune-mediated hepatitis after coronavirus disease 2019 vaccination, and clinicians should be aware of that potential side effect. Most patients who developed hepatitis after vaccination responded well to treatment with prednisolone, but an alternative type of vaccine should be considered for subsequent booster doses. Further prospective studies are required to investigate the duration of immunity and protection against different viral variants in patients with chronic liver diseases or liver transplant recipients, as well as the effect of heterologous vaccination.

Graphical Abstract

Keywords

COVID-19, SARS-CoV-2, Chronic liver disease, Liver transplantation, Vaccine, mRNA

Introduction

Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This contagious virus has infected millions of people worldwide resulting in significant morbidity and mortality. Patients with chronic illnesses, including those with chronic liver disease, are more prone to severe infections or infection-related complications.1 Moreover, patients with CLD, alcohol-associated liver disease and liver cirrhosis may have an impaired immune response to vaccination.1Figure 1 summarizes the mechanisms of reduced immune response in these groups of patients. There are currently four major types of COVID-19 vaccines approved by the World Health Organization (WHO), namely mRNA vaccines, adenoviral vector vaccines, inactivated vaccines and protein subunit vaccines. Studies focusing on these vaccines in patients with CLD are evolving. This review summarizes currently available data and evidence of the safety and efficacy of COVID-19 vaccines in this group of patients.

Mechanisms of reduced immune response in patients with chronic liver diseases.
Fig. 1  Mechanisms of reduced immune response in patients with chronic liver diseases.

The immune problems may be more pronounced in patients with coronavirus disease 2019 infection who have lymphopenia and reduced CD4 and CD8 T cells.

Risk and burden of COVID-19 infection in CLD patients

Chronic diseases increase the risk of mortality associated with COVID-19 infection. An international registry study of 745 patients with CLD and severe acute respiratory syndrome coronavirus 2 infection showed that the mortality rate was higher in patients with liver cirrhosis compared with those without (32% vs. 8%, p<0.001).2 Factors associated with higher mortality were advanced cirrhosis, older age, and alcohol-related liver diseases. Acute hepatic decompensation occurred in 46% of patients with liver cirrhosis and half of the patients with hepatic decompensation had acute-on-chronic liver failure.

An Asian study examined the impact of COVID-19 infection in 228 patients with CLD, of whom 43 had cirrhosis and 185 did not.3 Liver injury was progressive in 57% of patients, with a mortality rate of 43% in those with decompensated cirrhosis. Increasing bilirubin and aspartate aminotransferase (AST) levels and an aspartate aminotransferase/alanine aminotransferase (ALT) ratio >1.4 predicted mortality in cirrhosis patients.3 In a study in the USA, Singh et al.4 recruited a total of 2,780 patients with COVID-19 across 34 centers; 250 patients (9%) had pre-existing liver disease. They found that patients with pre-existing liver diseases, especially cirrhosis, were at higher risk for mortality [risk ratio (RR) 2.8; 95% confidence interval (CI), 1.9–4.0; p<0.001].4 Patients with cirrhosis had a higher relative risk of mortality than those without liver disease (risk ratio 4.6; 95% confidence interval, 2.6–8.3; p<0.001). Previous studies have shown that a 4- to 6-fold increase in the severity of COVID-19 in patients with metabolic-dysfunction associated fatty liver (MAFLD).5,6 The severity and mortality risk also increased in patients with higher fibrosis scores.7 Vaccination is one of the effective methods to protect the population from COVID-19, and is of the utmost importance in high-risk subgroups such as those with CLD.

WHO-approved vaccines

mRNA vaccines

The US Food and Drug Administration and the European Medicines Agency granted an emergency approval to two mRNA vaccines against COVID-19, the Pfizer BioNTech vaccine BNT162b2 (Comirnaty) and the Moderna mRNA-1273 vaccine (Spikevax). BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA (modRNA) vaccine.8,9 In adults 16 years of age or older, it is administered intramuscularly as two 30 µg doses in 21 days apart.10 It provides 95% protection against COVID-19 in the immediate post-vaccination period, but a gradual decline in efficacy over time was observed.11,12 A third booster dose of vaccine is important to maintain effectiveness over time or protect against the emergence of new variants.13 The mRNA-1273 vaccine is also a lipid-nanoparticle-encapsulated mRNA vaccine. It is administered as two 100 µg doses intramuscularly 1 month apart, in individuals 18 years of age or older.14,15 The vaccine efficacy was 94.1% as shown in the phase 3 randomized controlled trial (RCT, Supplementary Table 1).16

Effectiveness in CLD patients

There is a paucity of data from randomized controlled trials on mRNA vaccine safety and efficacy in patients with CLD and in liver transplant recipients (Table 1).17–36 Only 0.6% subjects in the phase 3 clinical trials of the two vaccines had liver disease.11,16 John et al.17 performed a retrospective cohort study of patients with cirrhosis (n=20,037) who received at least one dose of an mRNA vaccine at the Veterans Health Administration in the USA, and compared outcomes with a propensity score-matched unvaccinated control group.17 In the 28 days after the first dose of mRNA vaccine, there was no significant reduction in COVID-19 infection, indicating weakened early protection in patients with cirrhosis, but there was a 64.8% reduction in the risk from ≥28 days after the first dose. The vaccine-associated reduction in COVID-19 infections after the first dose was lower among patients with decompensated (50.3%) than with compensated cirrhosis (66.8%). In the 7 days after receiving a second dose of mRNA vaccine, there was a 78.6% reduction in COVID-19 infections and 100% reduction in COVID-19-related hospitalization or death in cirrhosis patients (Table 1).17

Table 1

Studies reporting the safety and efficacy of COVID-19 vaccines in patients with chronic liver disease or liver transplantation

Study and year [REF]Study typeVaccine usedType of liver disease (n)Median age, yearsEfficacy dataSafety data
John et al. 202117Retrospective cohort comparing vaccinated and unvaccinated patients with cirrhosisBNT162b2 or mRNA-1273Cirrhosis (40,074)69.1COVID-19 infections occurring ≥28 days after the first dose of vaccine were reduced by 64.8% in vaccinated vs. unvaccinated patients overall, by 50.3% in those with decompensated cirrhosis and by 66.8% in those with compensated cirrhosis. 7 days after the second dose of vaccine, three patients in vaccine group compared to 14 patients in control group developed COVID-19 infection, corresponding to a 78.6% reduction in COVID-19 infections. No vaccinated patient with cirrhosis was hospitalized or died from COVID-19 (100% protection).NR
John et al. 202218Retrospective cohort comparing outcomes of COVID-19 infection in vaccinated vs. unvaccinated patients with cirrhosisBNT162b2, mRNA-1273, or Ad.26.COV2.SCirrhosis (762)63.8 post-vaccination; 64.2 unvaccinatedVaccination was associated with a reduced overall risk of death within 60 days (aHR 0.21; 95% CI 0.10–0.42; p<0.0001), of COVID-19-related death (aHR 0.23; 95% CI 0.10–0.53; p=0.001), and of mechanical ventilation within 60 days (aHR 0.33; 95% CI 0.11–0.96; p=0.04) but did not reduce risk of hospitalization (aHR 0.88; 95% CI 0.66–1.18; p=0.41). In patients with decompensated cirrhosis, vaccination was associated with a reduction in risk of death (aHR 0.27; 95% CI 0.08–0.90; p=0.03) but not COVID-19-related deathNR
Bakasis et al. 202219Prospective cohort comparing patients with CLD and age- and gender-matched controlsBNT162b2 or mRNA-1273HBV (30), NAFLD (16), AIH (14), PBC (12), alcoholic liver disease (6), PSC (4), HCV (2), other (3)67S IgG seroconversion rate: cirrhosis: 37/38 (97.4%); CLD without cirrhosis: 43/49 (87.8%); controls: 40/40 (100%). Adequate neutralizing activity: cirrhosis: 35/38 (92.1%); CLD without cirrhosis: 43/49 (87.8%); controls: 40/40 (100%)Common AEs: pain at the injection site (40.2%), fatigue (14.2%), low-grade fever (9.5%) and headache (8%), with no statistically significant difference between CLD patients and controls. No cirrhotic patients showed post-vaccination liver-related AEs
Thuluvath et al. 202120Prospective cohort study comparing LT recipients, patients with cirrhosis, and patients with CLD but no cirrhosisBNT162b2, mRNA-1273, or Ad.26.COV2.SNAFLD (84), HBV/HCV (63), AIH/PBC/PSC (61), alcoholic liver disease (32), other (32)63 (mean)S IgG 4 weeks after 2 doses were: undetectable (<0.40 U/mL) in 11/62 LT recipients, 3/79 patients with cirrhosis and 4/92 patients with noncirrhotic CLD; suboptimal (0.40–250 U/mL) in 15/62 LT recipients (median titer 17.6, range 0.47–212 U/mL), 15/79 patients with cirrhosis (median titer 41.3, range 0.49–221 U/L), and 19/92 patients with noncirrhotic CLD (median titer 95.5, range 4.9–234 U/L)None of the patients had serious AEs. Common AEs after first dose were local pain at the injection site (53%) and fatigue (16%); and after second dose were local pain at the injection site (49%), fatigue (23%), fever (8%), chills (6%), headache (7%) and myalgia (6%)
Ruether et al. 202221Prospective observational study examining immunological response in patients with cirrhosis (n=48), LT recipients (n=138) and healthy controls (n=52)BNT162b2, mRNA-1273, or AZD1222Alcoholic liver disease (51), AIH (51), viral liver disease (20), cryptogenic (18), NAFLD (11), other (35)LT: 55; Cirrhosis: 53.8; Control: 50.9Anti-S trimer seroconversion rate: LT recipients: 63.0%; cirrhosis: 97.9%; control: 100%. Anti-S RBD seroconversion rate: LT recipients: 73.9%; cirrhosis: 100%; control: 100%. T-cell response rate: LT recipients 36.6%: cirrhosis: 65.4%; control: 100%. 28% of LT recipients had neither a humoral nor a T-cell response after second vaccinationCommon AEs included pain/swelling, fever, fatigue, headache, myalgia, and arthralgia, which did not differ between groups
Shafrir et al. 202222Retrospective study examining the relationship between liver fibrosis and immunological responseBNT162b2NAFLD56.7 (mean)The proportion of people with a strong vaccine response (S IgG >200 AU/mL) was significantly lower in those with high fibrosis ranges (elastography threshold >6 kPa)NR
Huang et al. 202225Prospective cohort study comparing immunological response in LT candidates and recipientsBNT162b2 or mRNA-1273NR61 (LT candidates); 62 (LT recipients)Anti-SARS-CoV-2 total Ig response. LT candidates (n=76): after first dose: 77.3%; after second dose: 100%. LT recipients (n=274): after first dose: 24.2%; after second dose: 51.2%. S IgG response. LT candidates (n=76): after first dose: 68%; after second dose: 100%. LT recipients (n=274): after first dose: 19.5%; after second dose: 42.5%NR
Toniutto et al. 202226Prospective cohort study comparing immunological response in LT recipients (n=143) and healthy controls (n=58)BNT162b2NR67.7Positive anti-S RBD response in LT recipients: 3 weeks after first dose: 22.1%; 1 month after second dose: 66.4%; 4 months after second dose: 77%; → median titer 32 U/mL; 6 months after second dose: 78.8%. Positive anti-S RBD response in controls:4 months after second dose: 100%; → median titer 852 U/mLNo severe AEs or significant liver test abnormalities. Systemic symptoms such as fever, asthenia, or myalgia, were reported in 12/58 (20.6%) controls and 7/143 (4.9%) LT patients (p<0.001)
Strauss et al. 202123Prospective observational cohort study examining immunological responseBNT162b2 or mRNA-1273LT recipients64Detectable anti-S1 or anti-S RBD IgG was seen in 34% (95% CI 27–42%) of patients after first dose (at a median of 21 days [IQR 109–25 days]), and in 81% (95% CI 74–87%) after second dose (at a median of 30 days [IQR, 28–31 days])NR
Rabinowich et al. 202124Prospective cohort comparing immunological response in LT recipients (n=80) and healthy controls (n=25)BNT162b2 or mRNA-1273HCV (26), NAFLD (16), HBV (13), AIH/PBC/PSC (16), Other (8)LT recipients: 60.1; Control: 52.7S IgG was detected in all controls but in only 38/80 (47.5%) LT recipients; A lower mean S IgG titer was found in LT recipients compared with controls (95.41±92.4 vs. 200.5±65.1 AU/mL; p<0.001)No major AEs occurred in any participant; Systemic symptoms after second dose of vaccine occurred in significantly fewer LT recipients compared with controls (25% vs. 85.7% respectively, p<0.001)
Davidov et al. 202227Prospective cohort study comparing immunological response in LT recipients (n=76) and age-mat c hed immunocompetent controls (n=174)BNT162b2HCV (19), NAFLD (13), PSC (11), HBV (7), PBC (3), other (23)LT recipients: 64Positive antibody response was documented 55/76 (72.4%) LT recipients compared with 164/174 (94.3%) controls (OR 6.26; 95% CI 2.8–14.1; p<0.0001), measured at a median 35 days after second vaccine dose. Mean (95% CI) titer of IgG antibodies was 2.1 (1.6–2.6) in LT recipients vs. 4.6 (4.1–5.1) in controls (p<0.0001), and of neutralizing antibodies was 150 (96–234) in LT recipients vs. 429 (350–528) in controls (p<0.001)No transplant rejection or allergic reactions at a mean follow-up of 30 days following the second dose; Local AEs developed in 30.3% after first vaccine dose and 19.7% after second dose
Herrera et al. 202128Prospective cohort study examining immunological response in transplant recipientsmRNA-1273LT recipients (58)61.522/58 LT recipients (37.9%) had IgM or IgG antibodies against S protein after first dose of vaccine and 41 (71%) after second dose; After second dose of vaccine, 50/58 (86%) showed positive cellular response in the IFN-γ assayCommon AEs were pain (80%), fatigue (15%), swelling (12%) and low-grade fever (7%); No rejection, and no significant changes in ALT or increase in HLA antibodies from baseline
Fernández-Ruiz et al. 202129Prospective cohort study examining immunological response in solid organ transplant recipients (n=44)mRNA-1273LT recipients (14)52.4 (mean, in the entire cohort)Cell-mediated immunity (IFN-γ assay) in 10/13 LT recipients and serum neutralizing activity in 5/13 at 2 weeks after completion of 2 dosesNo serious AEs and no graft rejection; ≥1 unsolicited AE reported by 12 recipients (27.3%): pain at the injection site (n=6), headache (n=3), fatigue (n=2), fever (n=1), tachycardia (n=1), and nausea (n=1)
Rahav et al. 202130Prospective cohort study examining immunological response in immunocompromised patients (n=1,002) and immunocompetent controls (n=272)BNT162b2LT recipients (36)NRPositive anti-RBD-IgG after second dose of vaccine 25/36 LT recipients (69.4%); anti-RBD-IgG geometric mean titer 2.14 (95% CI 1.46–3.14) and neutralizing antibody geometric mean titer 264.6 (95% CI: 121.8–574.9)In all solid organ transplant recipients, 26.7% reported local AEs and 24% reported systemic AEs after second dose of vaccine
Nazaruk et al. 202131Retrospective cohort examining immunological response in kidney transplant and LT recipientsBNT162b2LT recipients (55)58.4 (mean)In LT recipients, anti-S1 antibody response in 63% after first dose and 88.9% after second doseNR
Boyarsky et al. 202132Prospective cohort examining immunological response in kidney transplant and LT recipientsBNT162b2 or mRNA-1273LT recipients (129)NRIn LT recipients, 26/129 (20%) were nonresponders, 41/129 (32%) had an anti-S1 or anti-S RBD response after first and second vaccine doses and 62/129 (32%) had a response after the second dose but not the firstNR
Ai et al. 202233Prospective cohort study examining the immunological response and safety in patients with CLD (n=437) and healthy volunteers (n=144)BBIBP or WIBPCHB (384), CHC (20), NAFLD (12), AIH/PBC/PSC (8), alcoholic liver disease (1), other (12)47SARS-CoV-2 neutralizing antibody (>10 AU/mL) positivity was seen in 338/437 patients with CLD (77.3%), 120/153 patients with cirrhotic CLD (78.4%), 218/284 with noncirrhotic CLD (76.8%), and 13/144 controls (90.3%)Common AEs were pain at the injection site (8.2%), fatigue (1.8%), low-grade fever (2.1%); 3/164 participants with follow-up laboratory data (1.8%) had grade 3 ALT elevation and 4/164 (2.4%) had grade 2 AST elevation
He et al. 202234Prospective cohort study examining the immunological response and safety in patients with CHB (n=362) and healthy controls (n=87)BBIBPCHB (362)CHB: 45; Control: 44Seropositivity rates of SARS-CoV-2 antibodies 3 months after full-course of vaccination were: S IgG in 63/66 CHB patients (95.5%) and 30/32 controls (93.8%); RBD-specific IgG in 65/66 CHB patients (98.5%) and 31/32 controls (96.9%); RBD-ACE 2 blocking antibody in 29/66 CHB patients (43.9%) and 9/32 controls (28.1%)Common AEs included pain at the injection site (5.8%), fatigue (4.7%), dizziness (1.9%)
Xiang et al. 202135Prospective observational study examining the immunological response and safety in CHB patients who were unvaccinated (n=81) or had received 1 (n=54) or 3 (n=149) vaccine dosesBBIBPCHB (248)41In patients who completed the two doses of the vaccination regimen (n=149), seropositivity for anti-S-RBD-IgG was 87.25% and for neutralizing antibodies 74.5%Common AEs were pain at the injection site (25.5%), fatigue (1.3%), drowsiness (2.0%)
Wang et al. 202136Prospective observational study examining the immunological response and safety in patients with NAFLDBBIBPNAFLD (381)39Neutralizing antibodies against SARS-CoV-2 were detected in 364/381 (95.5%) patients; median neutralizing antibody titer was 32 (IQR 8–64)Common AEs were injection site pain (18.4%), muscle pain (5.5%), headache (5.2%), and fatigue (4.7%)

ACE, angiotensin converting enzyme; AE, adverse event; aHR, adjusted hazard ratio; AIH, autoimmune hepatitis; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CHB, chronic hepatitis B; CHC, chronic hepatitis C; CI, confidence interval; CLD, chronic liver disease; HBV, hepatitis B; HCV, hepatitis C; HLA, human leukocyte antigen; IFN-γ, Interferon gamma; IgG, Immunoglobulin G; IQR, interquartile range; LT, liver transplant; NAFLD, nonalcoholic fatty liver disease; NR, not reported; OR, odds ratio; PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis; RBD, receptor-binding domain; S IgG, anti-SARS-CoV-2 S-spike immunoglobulin G, S1 subunit 1; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2.

Because the protection from COVID-19 infection was lower in patients with cirrhosis than in healthy individuals in randomized controlled trials, post-vaccination breakthrough infection is expected. However, while infection cannot be completely avoided, vaccination in cirrhosis patients is still beneficial. A retrospective cohort study compared the outcome of COVID-19 infection in cirrhosis patients, 254 of whom had been vaccinated and 508 of whom were unvaccinated.18 There was a reduction in the risk of overall mortality [adjusted hazard ratio (aHR) 0.21; 95% CI: 0.10–0.42; p<0.0001] and COVID-19-related death (adjusted hazard ratio 0.23; 95% CI: 0.10–0.53; p=0.001) within 60 days in vaccinated patients.18 The decrease in mortality was seen in cirrhosis patients after full (adjusted hazard ratio 0.22; 95% CI: 0.08–0.63; p=0.005) or partial (aHR 0.19; 95% CI: 0.07–0.54; p=0.002) vaccination.18 The significant reduction in COVID-19-related death was seen in patients with compensated cirrhosis (aHR 0.16; 95% CI: 0.06–0.46; p=0.0001) but not those with decompensated cirrhosis (aHR 0.51; 95% CI: 0.14–1.88; p=0.31).18

Although decompensated cirrhosis is a risk factors for lower vaccine response,37 multiple studies substantiate an antibody response after mRNA vaccine in that group of patients. In a prospective cohort study of 87 patients with CLD, including 38 (43.7%) with cirrhosis and 30 (34.5%) under immunosuppressive treatment, seroconversion rates were 97.4% in cirrhotic patients, 87.8% in noncirrhotic patients and 100% in controls, based on levels of anti- severe acute respiratory syndrome coronavirus 2 S-spike immunoglobulin G (S IgG) antibodies.19 Adequate neutralizing activity was detected in 92.1%, 87.8% and 100% of patients with cirrhosis, without cirrhosis, and controls, respectively.19 Immunosuppressive therapy was associated with lower anti-SARS-CoV-2 antibody titers [coefficient±standard error (SE) −2.716±0.634; p<0.001] and neutralizing activity (coefficient±SE −24.379±4.582; p<0.001).19 In a study by Thuluvath et al.,20 in which more than 90% of the included patients received mRNA vaccine, poor antibody responses were seen in 61% of liver transplant recipients and 24% of those with CLD. However, after adjusting for other variables, liver cirrhosis was not associated with poor antibody responses. Among the suboptimal responders, higher median antibody titers were observed in patients with CLD compared with liver transplant recipients.20 Similar results were demonstrated in a study by Ruether et al.,21 in which patients with liver cirrhosis and controls had comparable vaccine-specific humoral immune responses and T-cell responses after vaccination.21 All these findings support the use of mRNA vaccine in patients with CLD including those with cirrhosis.

Shafrir et al.22 analyzed the correlation between the degree of liver fibrosis, using a fibrosis-4 score, in which age, aspartate aminotransferase, alanine aminotransferase, and platelet count are included38 and serum S IgG titers in 511 employees at a medical center. The higher the fibrosis-4 score, the lower the serum S IgG titers (p=0.004).22 The association was further confirmed by FibroScan in another 76 patients with nonalcoholic fatty liver disease (NAFLD) who received an mRNA vaccine. Among patients with results in the high fibrosis range on transient elastography, a lower proportion achieved a strong vaccine response in terms of antibody titer compared with patients who had low fibrosis scores.22

Efficacy in liver transplant recipients

A suboptimal response to mRNA vaccines in liver transplant recipients has been consistently demonstrated in various studies, although it is difficult to compare results because of different methods/parameters used to measure antibody response and the different assay sensitivities.39 A number of studies suggest that only about half of the liver transplant recipients who received a COVID-19 mRNA vaccine developed an immune response. Strauss et al.23 described the antibody response in 161 liver transplant recipients, 53% of whom had received BNT162b2 and 47% mRNA-1273. Around one-third of the patients had an antibody response after the first dose of mRNA vaccine, 47% responded after the second dose, and 19% were nonresponders. Risk factors for a diminished vaccine response included vaccination within 6 years from transplant or vaccination with BNT162b2 compared with mRNA-1273.23 In the study by Ruether et al.,21 almost half of the liver transplant recipients had suboptimal humoral responses and more than one-quarter were potentially immunologically unprotected even after the second vaccination. Another prospective cohort study including 80 liver transplant recipients found that around half the liver transplant recipients were seronegative, and in transplant recipient who had a response, the antibody titer was lower than in control group (mean 95.41±92.4 vs. 200.5±65.1 AU/mL, p<0.001).24 In a study by Huang et al.,25 68% of liver transplant candidates developed reactive S IgG responses after a single dose of mRNA vaccine and 100% responded after two doses, compared with only 19.5% and 42.5%, respectively, of liver transplant recipients.25 Multivariable logistic regression found that transplant candidates had a 14 times higher likelihood of having a positive immune response to a single dose of mRNA vaccine compared with transplant recipients (odds ratio 14.6; 95% CI: 2.19–98.11; p=0.02).25 Other studies reported a higher rate of response to mRNA vaccines against COVID-19, with at least 70% of liver transplant recipients responding. A positive anti-severe acute respiratory syndrome coronavirus 2 S-receptor-binding domain antibody (anti-S-RBD) response was seen in 77% of liver transplant recipients compared with 100% of controls at 4 months after the second dose of BNT162b2 in a prospective cohort by Toniutto et al.26 However, the transplant recipients had a significantly lower median S-receptor-binding domain antibody titers (32 U/mL vs. 852 U/mL; p<0.0001).26 Davidov et al.27 reported a 72% response rate to the BNT162b2 mRNA vaccine in 76 liver transplant recipients. Vaccination in the first year after transplant and hypogammaglobulinemia were independent risk factors for a poor response to the mRNA vaccines.28 The high response rate reported by Davidov et al.27 may have been related to the relatively long median time from transplant of 7 years and a low immunosuppressive burden.27

It should be noted that there is discordance between vaccine-induced cell-mediated and neutralizing humoral immunities in transplant recipients.29 For example, around 19% of seronegative patients exhibited detectable cell-mediated immunity in a study by Fernández-Ruiz et al.29 The reason is not clear, but immunosuppressant drugs are known to have differential effects on T-cell subsets, including the CD4 subsets involved in the generation of long-lived plasma cells. Therefore, it is possible that some transplant recipients have sufficient T-cell populations to mount a cytotoxic cell-mediated response to the COVID-19 vaccine, but not sufficient to generate detectable levels of antibody.29

Liver transplant recipients appear to have a better vaccine response compared with people with transplants of other solid organs.28–30 For example, a prospective cohort study recruited 1,002 immunocompromised patients, including 36 with liver, 111 with kidney, and 80 with heart transplants.30 The proportions of transplant recipients achieving an effective anti-receptor-binding domain antibody response and neutralizing antibodies 2–4 weeks after the second vaccine dose were 69.4%, 45% and 18.8%, respectively.30 An unexpectedly high BNT162b2 vaccine efficacy (88.9%) was found in patients who had received a liver transplant compared with a kidney transplant (57.1%).31 That may be related to renal function, as a decreased estimated glomerular filtration rate (eGFR) is a negative predictor of vaccination response.21,24,26 In addition, the fact that the liver is an immunologically privileged organ, and liver transplant recipients usually require less immunosuppressive therapy than recipients of other solid organ transplants, might also explain the better response to vaccination.31

The type of immunosuppressive therapy has an important impact on vaccine efficacy in liver transplant recipients. In the studies described above, the use of mycophenolate mofetil, particularly high daily doses, or antimetabolites, was associated with poor vaccine response.23,24,26,28 A higher proportion of organ transplant recipients using antimetabolites are nonresponders.32 A lower antibody response was also seen in patients on combination immunosuppression compared with calcineurin inhibitor monotherapy.27 Use of high-dose prednisone in the previous 12 months and triple immunosuppressant therapy were significant predictors of impaired serologic response to mRNA vaccines in liver transplant recipients.24 The tacrolimus dose at vaccination was negatively correlated with the increase in anti-S1 Ab titer after completion of the second vaccine dose in patients who had undergone liver transplantation.31

Safety and tolerability

An interim analysis of surveillance of 6.2 million unselected individuals who had received a total of 11,845,128 doses of mRNA vaccines showed no significant concern regarding serious outcomes like arterial or venous thromboembolism, Bell palsy, Guillain-Barré syndrome, myocarditis/pericarditis, or thrombosis with thrombocytopenia syndrome.40 The occurrence of adverse events was reported to be higher with mRNA-1273 than with BNT162b2, but mRNA-1273 is less temperature sensitive and therefore easier to transport and store.41

There have been reports of liver injury with no other clear precipitants following COVID-19 vaccination.42,43 A multicenter case series of 16 patients who presented with liver injury after mRNA vaccine reported that all 10 patients with liver biopsies had portal inflammation and five had a significant plasma cell component. Those ten patients were treated with prednisone.44 This raises the concern that COVID-19 vaccines may cause immune-mediated hepatitis or drug-induced liver injury (Table 2).42–59 Molecular mimicry and bystander activation have been suggested as potential mechanisms for autoimmunity.60,61 Upregulation of proinflammatory signals, especially the type I interferon response caused by mRNA binding to Toll-like receptors may also trigger autoimmune hepatitis (AIH).56,62 In patients with autoimmune hepatitis, re-exposure to the vaccine may trigger fulminant hepatitis.54 Therefore, physicians should vigilantly manage patients who present with liver injury and recent vaccination and consider another class of vaccine for subsequent booster doses.

Table 2

Case reports or case series of liver injury following SARS-CoV-2 vaccination

StudyAgeSexType of vaccineTime to presentationDrug historyAutoimmune diseaseAntibodiesIgG (g/L)ALT level at diagnosis (U/L)Liver biopsyTreatmentOutcome
mRNA vaccine
Alqarni et al. 20214214FBNT162b23 days after second doseNilNilNegativeNil4,500NilNAC, lactulose, vitamin K, and empirical antibioticLFT gradually improved by the seventh day
Dumortier J 2022 4346MBNT162b212 days after first doseAspirin, tacrolimus and MMF (post liver transplant)NilNegativeNil287NilNilNormalization of ALT, AST and ALP in 1 month
Shroff et al. 2021 4425–74M: 6; F: 10BNT162b2 (n=12); mRNA-1273 (n=4)5–46 days after first dose, with 12 patients presenting after second doseAntibiotic: 2; NSAID: 2; Paracetamol: 2AIH: 4ANA: 5; ASMA: 4Elevated in one patient96 to >5,000Performed in 10 patients: Portal inflammation: 10; Plasma cell infiltration: 5; Cholestasis and bile duct reaction: 17 patients treated with steroidAll patients were either recovering or fully recovered
Lodato et al. 20214543FBNT162b22 days after second doseGinkgo-biloba >100 days before admissionNilNegativeNA171Moderate portal inflammatory infiltrate and interface hepatitis in the portal tract with biliary injury and mild ductular proliferation; Spotty necrosis, lymphocytes along the sinusoid, focal moderate steatosis, and intranuclear glycogen inclusions in the lobule; Immunostaining with cH7-Ab showed mild ductular proliferation and diffuse immunoreactivity in hepatocytes zone 1–2Methyl-prednisolone 1 mg/kg/dayLFT completely normalized in 8 weeks
Bril et al. 20214635FBNT162b213 days after first doseLabetalolNilANA; Anti-dsDNA10.81 (not elevated)2,001Pan-lobular hepatitis; Intense lymphoplasmacytic infiltrate effacing the interface with rosette formation; Primarily lymphocytic inflammation with plasma cells and eosinophils; Scattered hepatocyte necrosisPrednisolone 20mg dailyNormalization of LFT in around 2 months
Avci et al. 2021 4761FBNT162b21 month after first doseValsartan and levothyroxineHashimoto’s thyroiditisANA; ASMA42.6↑455Narrow sinusoids and lymphocyte infiltration; Severe portal and peri-portal lymphocyte infiltration; Peri-septal interface hepatitis, spotty necrosis, and limiting plate disorder; Mild fibrosisPrednisolone 40mg daily, then azathioprine added, and steroid dose taperedImproved to mildly elevated transaminase and bilirubin on day 35
Palla et al. 20224840FBNT162b21 month after second doseNilNilANA24↑4 x ULNActive hepatitis with significant interface necroinflammation and severe lobular inflammatory infiltration composed predominantly of lymphocytes with an admixture of plasma cells; Portal/periportal fibrosis was evident as well as fibrous septa with occasional bridgingPrednisolone 40mg dailyLFT normalized 1 week after start of treatment
Rocco et al. 20214980FBNT162b21 week after second doseLevothyroxine, pravastatin, and aspirinHashimoto’s thyroiditisANA35↑1,186Interface hepatitis with a moderate degree of lymphoplasmacytic infiltrate and multiple confluent foci of lobular necrosis with Councilman bodiesPrednisolone 1 mg/kg/dayProgressive improvement in LFT in 2 months
Garrido et al. 20215065FmRNA-12732 weeks after first dosePegylated interferon, aspirin, sertraline, and esomeprazoleNilANA20↑1,092Marked expansion of the portal tracts due to dense inflammatory infiltrate, with aggregates of plasma cells; severe interface hepatitis and multiple confluent foci of lobular necrosisPrednisolone 60mg dailyQuick improvement of LFT and normalization of IgG levels after start of prednisolone
Vuille-Lessard et al. 20215176FmRNA-12732–3 days after first doseLevothyroxine, midodrine, and zolpidemHashimoto’s thyroiditisANA; ASMA; Anti-actin antibody; ANCA39.4↑579Chronic markedly active hepatitis with interface hepatitis, plasma cells, feathery degeneration, and pseudorosettesPrednisolone 40mg daily; Azathioprine was added 14 days laterLFT completely normalized in 4 weeks after treatment
Ghielmetti et al. 20215263MmRNA-12737 days after first doseMetformin, aspirin, and rosuvastatinNilANA; Anti-parietal cell antibody19.96↑1,038Intense lymphoplasmacytic infiltrate with scattered eosinophils, interface hepatitis, and centrilobular necrosisPrednisolone 40mg dailyImprovement in LFT 2 weeks after treatment
Tan et al. 20215356FmRNA-12736 weeks after first doseRosuvastatinNilANA; ASMA32.6↑1,701Portal inflammation with interface hepatitis, conspicuous lobular inflammation with the presence of plasma cell aggregates, rosette formation, and apoptotic hepatocytes; A few eosinophils were identified; Early young fibrosisBudesonideRapid clinical and biochemical improvement after start of steroid
Zin Tun et al. 20225447MmRNA-12733 days after first doseNilNilANA25.1↑1,048Widespread areas of bridging necrosis, marked interface hepatitis, lymphoplasmatic inflammation including eosinophils, ballooned hepatocytes, multinucleated giant cells, and emperipolesis; Minimal fibrosisPrednisolone 40mg dailyPT normalized within 2 weeks
McShane et al. 20215571FmRNA-12734 days after first doseParacetamol 2 g within 24 h after vaccinationNilASMA21.77↑1,067Marked polymorphous inflammatory cell infiltrate of plasma cells, lymphocytes, eosinophils, neutrophils, and PASD-positive ceroid laden macrophages; Interface hepatitis with portal-portal and portal-central bridging necrosisPrednisolone 40mg dailyLFT continued to improve on a tapering course of prednisolone
Londoño et al. 20215641FmRNA-12737 days after second doseHormonal replacement therapyNilANA; ASMA; Anti-SLA; Anti-liver cytosol20.8↑1,312Marked expansion of the portal tracts with a dense inflammatory infiltrate composed of lymphocytes and plasma cells, severe interface hepatitis, and lobular inflammation with disperse necroinflammatory foci, apoptotic bodies, and hepatocyte ballooning; No signs of parenchymal or perisinusoidal fibrosisPrednisolone 1 mg/kgRapid normalization of LFT after start of prednisolone
Adenoviral vector vaccine
Clayton-Chubb et al. 20215736MAZD122226 days after first doseOlmesartan, paracetamol, ibuprofenNilANA12.8 (not elevated)1,774Significant interface hepatitis with a mixed, predominantly lymphocytic, inflammatory cell infiltrate without significant fibrosisPrednisolone 60mg dailyLFT improvement with gradual tapering of steroid
Rela et al. 2021 5838FAZD122220 days after first doseLevothyroxineHypothyroidismANA16.5↑1,025Multiacinar hepatic necrosis and diffuse portal/periportal neo-cholangiolar proliferation; Inflammation comprising of lymphocytes, plasma cells, and rare eosinophils were noted; Sinusoidal pigment laden histiocytes and central venulitis were noted, and suggestive of AIHPrednisolone 30mg dailyLFT normalization with gradual tapering of steroid
62MAZD122216 days after first doseNilNilNegativeNil1,094Porto-central bridging necrosis; Portal/periportal neocholangiolar proliferation and mild to moderate inflammation comprising of lymphocytes along with plasma cells, eosinophils, and polymorphs; Focal rosetting and emperipolesis; Patchy hepatocanalicular bilirubinostasis and central venulitis; Mild portal fibrosis (Ishak stage 2/6)Prednisolone 30mg daily; 5 cycles of therapeutic plasma exchangePoor response to treatment; patient died 3 weeks after admission
Inactivated virus vaccine
Ghorbani et al. 20225962MSinopharm3 days after second doseMetformin, glibenclamide and losartanNilNilNil722Severe infiltration of lymphocytes, eosinophils, and neutrophils in portal tract (score: 3/4) and lobules (score: 4/4) accompanied by interface hepatitis (score: 4/4) and feathery change. Foci of ductular reaction; Final grading and staging, according to Ishak modified hepatitis activity index, were 11/18 and 1/6, respectivelyUrsodeoxy-cholic acidLiver enzymes gradually improved

AIH, autoimmune hepatitis; ALP, alkaline phosphatase; ALT, alanine aminotransferase; ANA, antinuclear antibody; ANCA, anti-neutrophil cytoplasmic antibodies; Anti-dsDNA, anti-double stranded DNA; anti-SLA, anti-soluble liver antigen; ASMA, anti-smooth muscle antibody; AST, aspartate aminotransferase; IgG, Immunoglobulin G; LFT, liver function test; MMF, mycophenolate mofetil; NAC, N-acetylcysteine; NSAID, nonsteroidal anti-inflammatory drug; PASD, periodic acid–Schiff with diastase digestion; PT, prothrombin time; ULN, upper limit of normal.

Adenoviral Vector Vaccines

AZD1222

The AstraZeneca ChAdOx1 nCoV-19 vaccine (AZD1222, Covishield or Vaxzevria) is an adenoviral vector vaccine that consists of a replication-deficient chimpanzee adenoviral vector ChAdOx1 that contains the SARS-CoV-2 structural surface glycoprotein antigen (spike protein; nCoV-19) gene.63 A phase 3 randomized controlled trial recruited 32,451 participants ≥18 years of age and randomized them in a 2:1 ratio to receive AstraZeneca ChAdOx1 nCoV-19 vaccine (n=21,635) or placebo (n=10,816).64 The two doses of AstraZeneca ChAdOx1 nCoV-19 vaccine, each containing 5×1010 viral particles, were administered 4 weeks apart. The percentage of individuals with liver diseases was 1.5% in each group, but the types of liver diseases were not reported. The overall efficacy of preventing symptomatic illness 15 days or more after the second dose was 74%. The estimated vaccine efficacy against COVID-related hospitalization was 94.2%.64 A third dose of vaccine, either of the same class or a different class, boosted neutralizing antibody, and T-cell responses.65,66 The vaccine was safe, with low incidences of serious (0.5%) and medically attended adverse events.64 However, there were safety concerns of the thrombotic risk associated with the vaccine.67 A pathogenic PF4-dependent syndrome that occurred after the administration of the vaccine and was unrelated to the use of heparin was identified.68 The mechanism mimicked autoimmune heparin-induced thrombocytopenia.69 Treatment included intravenous immune globulin and a nonheparin anticoagulant.70 Clinicians should pay special attention to vaccine recipients with thrombotic risk factors. Another concern are reports of autoimmune hepatitis in people after receiving AZD1222. Most patients who developed vaccine-related hepatitis responded well to treatment with prednisolone.57,58 However, one patient had a poor response to prednisolone and courses of plasma exchange and died 3 weeks after admission (Table 2).58

Ad26.COV2.S

The Ad26.COV2.S vaccine (Jcovden, Johnson & Johnson). Is an adenoviral vector vaccine consisting of a recombinant, replication-incompetent human adenovirus type 26 (Ad26) vector encoding a full-length and membrane-bound SARS-CoV-2 spike protein in a prefusion-stabilized conformation.71,72 The key phase 3 study included 39,321 participants randomized in a 1:1 ratio to receive a single dose of Ad26.COV2.S or placebo.73 Patients with liver diseases comprised 0.5% of the populations in each arm of the study. There were 66 cases of moderate-to-severe critical COVID-19 in the vaccine group and 193 cases in the placebo group, yielding a vaccine efficacy of 66.1% (adjusted 95% CI, 55.0–74.8%). To date, there are no published data reporting on the safety and efficacy of AZD1222 or Ad26.COV 2.S vaccines in liver transplant recipients or patients with CLD. Further research is needed.

Inactivated virus vaccines

Two inactivated COVID-19 vaccines have been approved and are used in some countries. They are CoronaVac developed by Sinovac Life Sciences and the Sinopharm vaccine. Inactivated vaccines can induce a wide range of cellular and humoral responses, but their disadvantages include limited immunogenicity, which requires adjuvants to enhance the immune response, the need to handle large quantities of live virus, and the integrity of antigens or epitopes that must be verified.74 Tanriover et al.75 conducted a phase 3 study on CoronaVac using two doses of 3 µg inactivated SARS-CoV-2 virion in a 0.5 mL aqueous suspension administered 14 days apart. The estimated efficacy of the vaccine was 83.5%. The results of other RCTs on inactivated vaccines are shown in Supplementary Table 1.76–78

Emerging evidence shows that a booster dose is needed for people who have received two doses of inactivated vaccine.79–83 A recent study showed that the initial neutralizing antibody response to two doses of CoronaVac declined to near or below the lower limit of seropositivity after 6 months.84 A third dose of CoronaVac (3 µg) given 8 months after the second dose resulted in a strong, immunogenic boost.84

Efficacy and safety in patients with CLD or liver transplants

The use of inactivated vaccine and its antibody response have been studied in patients with CLD or liver transplant recipients. The largest was conducted by Ai et al.33 and included 581 participants, 437 with CLD, and 144 healthy volunteers from 15 sites in China.33 CLD included liver diseases of more than 6 months duration, including chronic inflammation from conditions like hepatitis B, hepatitis C, NAFLD, alcoholic liver disease, autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, with or without liver cirrhosis. Two doses of inactivated whole virion SARS-CoV-2 vaccine were given to all participants 3 to 8 weeks apart. Serum samples were taken 14 days or more after the second dose and tested for SARS-CoV-2 neutralizing antibody. The positive rates of neutralizing antibodies were 76.8% in the group with noncirrhotic CLD, 78.9% in the group with compensated cirrhosis, 76.7% in the group with decompensated cirrhosis, and 90.3% in healthy controls. The immunogenicity rates were similar across different CLD groups (p=0.894) but were significantly lower than in the healthy population (p=0.008).33 Most adverse reactions were mild and transient. Injection site pain was the most commonly reported adverse event, with an incidence of 8.2%.33 Comparable safety was shown in patients with noncirrhotic CLD, compensated cirrhosis, and decompensated cirrhosis. Three participants had grade 3 aminotransferase elevations, defined as an alanine aminotransferase level >5 times the upper limit of normal after the second dose of vaccine. In one of those participants, it was regarded as a severe adverse event potentially related to the vaccination. The patient had discontinued antiviral agents against hepatitis B before SARS-CoV-2 vaccination. Therefore, it was uncertain whether the severe adverse event was related to the vaccination or to hepatitis B reactivation after discontinuation of antiviral treatment.33

Several studies have investigated the efficacy of inactivated SARS-CoV-2 vaccines in hepatitis B patients. He et al.34 conducted a study in 362 chronic hepatitis B (CHB) patients and 87 healthy controls who received two doses of inactivated vaccine at an interval of at least 21 days. Researchers analyzed the antibody profiles of the anti-spike IgG, anti-RBD IgG, and RBD-angiotensin-converting enzyme 2 (RBD-ACE2) blocking antibody at 1, 2, and 3 months, as well as levels of SARS-CoV-2 specific B cells. chronic hepatitis B patients had lower titers of the three antibodies than healthy controls at 1 month, but seropositivity rates of the three antibodies were similar in chronic hepatitis B patients and healthy controls at 2 and 3 months. Patients who were positive for hepatitis e-antigen (HBeAg) had higher titers of all three antibodies at 3 months (all p<0.05) and a slower decline in antibody titers compared with healthy controls.34 Atypical memory B-cells (MBCs) are a subset short-lived activated cells that ate plasma cell (PC) precoursors.85 The percentage of Atypical memory B-cells is usually increased in patients with chronic diseases.86 The number of RBD+ memory B-cells was higher in HBeAg-positive CHB patients than in controls at 3 months. It was proposed that the higher frequency of RBD+ atypical MBCs in HBeAg-positive CHB patients would lead to a higher frequency of plasma cells, which might then result in higher antibody titers.85

A study by Xiang et al.35 recruited 284 CHB participants, of whom 81 were unvaccinated, 54 who had received the first dose of vaccine and 149 who had received two doses of vaccine. The seropositivity rates for anti-S-RBD-IgG and neutralizing antibody was 87.25% and 74.5%, respectively for participants with two doses of inactivated vaccines.35 In addition, the study showed that the hepatitis B patients receiving nucleos(t)ide analog therapy had a significantly higher neutralizing antibody titer than those who had not (p<0.05).35 The reason is not clear, but it was proposed that long-term antiviral therapy for hepatitis B inhibited viral replication and led to the recovery of the impaired immune system by restoring the function of circulating T cells, natural killer cells, or dendritic cells. The effects would be more prominent in patients receiving nucleotide analogs that induce the production of interferon-α3.87,88 It is therefore recommended to continue administration of nucleos(t)ide analogs during vaccination to avoid negatively impacting CHB treatment.

Wang et al.36 conducted a multicenter study in 381 patients with nonalcoholic fatty liver disease and without a history of SARS-CoV-2 infection who were being treated at 11 designated centers in China. All nonalcoholic fatty liver disease patients were given with two doses of inactivated vaccine. Levels of neutralizing antibody against SARS-CoV-2 were measured at least 14 days after the full vaccination course. Antibodies were detected in 364 (95.5%) patients. The median neutralizing antibody titer was 32 (interquartile range 8–64), and the median period between the completion of vaccination and neutralizing antibody detection was 39.0 days (interquartile range 35–50 days).36 Inactivated vaccines have shown their efficacy in patients with different types of CLD. The adverse effects were mild and self-limiting and there were few reports of vaccine-induced hepatitis in patients with CLD after receiving this type of vaccine.59

Protein subunit vaccines

The Novavax NVX-CoV2373 vaccine (Nuvaxovid, Covovax) is a recombinant SARS-CoV-2 nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins and Matrix-M1 adjuvant.89 The two vaccine components trigger both B- and T-cell immunity to the SARS-CoV-2 S protein, and the full-length S protein has common epitopes that could protect against variants.90 It is given intramuscularly as two 5 µg doses, 21 days apart.91 A phase 3 randomized trial included 15,187 participants (14,039 of whom were included in the per-protocol analysis). Vaccine efficacy against both B.1.1.7 (alpha) and non-B.1.1.7 variants was 89.7% (95% CI: 80.2–94.6%).92 Similar levels of protection were shown in another phase 3 trial including 29,949 adults in the USA and Mexico, with B.1.1.7 the most sequenced viral strain.93 The vaccine efficacy of NVX-CoV2373 against any variant was 92.6% (95% CI: 83.6–96.7%), but lower protection, a vaccine efficacy of 49.4%. was found against B.1.351 variants.94 The efficacy of NVX-Cov2373 may be affected by coexisting illnesses with a higher number needed to treat to prevent COVID-19 infection in individuals with comorbidities.95 In patients living with stable HIV-1 infection, viral load of <1,000 copies/mL, and on stable antiretroviral therapy for ≥8 weeks, the humoral immune response to NVX-CoV2373 was attenuated compared with HIV-negative vaccine recipients.96 HIV-positive participants were more likely to have underlying comorbidities (36.1% vs. 22.2%) and hepatitis B surface antigen positivity (7.0% vs. 1.0%) compared with HIV-negative vaccinees.96 In the phase 3 studies by Heath et al.92 and Dunkle et al.,93 more than 40% of the participants had coexisting illnesses but the percentages of patients with CLD were not reported. At the time of writing, there are no studies reporting the safety or efficacy of NVX-Cov2373 in liver transplant recipients or patients with CLD. Future research is needed to guide immunization decisions in those patients. Most of the reported solicited local and systemic adverse events after receiving NVX-Cov2373 were mild to moderate and transient. Common solicited systemic adverse events included headache, myalgia, fatigue, and fever. There were no episodes of anaphylaxis, Guillain Barré syndrome, vaccine-induced immune thrombotic thrombocytopenia, or an increased risk of myocarditis or pericarditis, although the follow-up period in the phase 3 studies was relatively short.93,94

Conclusion

COVID-19 vaccination in cirrhosis patients reduced overall mortality, and they should be vaccinated unless there are contraindications. Liver transplant recipients may benefit from an early third booster dose to achieve a better protective effect. Currently, there are more data supporting the use of mRNA vaccines compared with other COVID-19 vaccines in patients with CLD. Recent evidence also shows that the mRNA vaccines and ChAdOx1 nCoV-19 vaccine are useful against new strains such as the omicron variants.97,98 Clinicians should remain cautious about the potential for vaccine-induced immune-mediated hepatitis or drug-induced liver injury. More research is needed on the duration of immunity, need for booster doses, effects of heterologous vaccination, and protection against novel variants in patients with CLD or liver transplant recipients.

Supporting information

Supplementary Table 1

Studies showing safety and efficacy of WHO-approved COVID-19 vaccines.

(DOCX)

Click here for additional data file.

Abbreviations

Ad26: 

adenovirus type 26

Ahr: 

adjusted hazard ratio

AIH: 

autoimmune hepatitis

ALT: 

alanine aminotransferase

AST: 

aspartate aminotransferase

CHB: 

chronic hepatitis B

CI: 

confidence interval

CLD: 

chronic liver diseases

COVID-19: 

coronavirus disease 2019

MBC: 

memory B-cells

NAFLD: 

nonalcoholic fatty liver disease

RBD: 

receptor-binding domain

RCT: 

randomized controlled trial

RR: 

risk ratio

SARS-CoV-2: 

severe acute respiratory syndrome coronavirus 2

Declarations

Acknowledgement

The authors would like to thank Catherine Rees, for editing the manuscript prior to submission.

Funding

None to declare.

Conflict of interest

The authors have no conflicts of interest related to this publication.

Authors’ contributions

Study concept and design (CKC, MFL), acquisition of data (CKC, KWT, AWH, RH, MFL), analysis and interpretation of data (CKC, KWT, AWH, RH, MFL, SHW), drafting of the manuscript (CKC, MFL), critical revision of the manuscript for important intellectual content (CKC, SHW, MFL). All authors have made a significant contribution to this study and have approved the final manuscript.

References

  1. European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol 2018;69:406-460 View Article PubMed/NCBI
  2. Marjot T, Moon AM, Cook JA, Abd-Elsalam S, Aloman C, Armstrong MJ, et al. Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study. J Hepatol 2021;74(3):567-577 View Article PubMed/NCBI
  3. Sarin SK, Choudhury A, Lau GK, Zheng M-H, Ji D, Abd-Elsalam S, et al. Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; the APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study). Hepatol Int 2020;14:690-700 View Article PubMed/NCBI
  4. Singh S, Khan A. Clinical Characteristics and Outcomes of Coronavirus Disease 2019 Among Patients With Preexisting Liver Disease in the United States: A Multicenter Research Network Study. Gastroenterology 2020;159(2):768-771.e3 View Article PubMed/NCBI
  5. Zheng KI, Gao F, Wang XB, Sun QF, Pan KH, Wang TY, et al. Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease. Metabolism 2020;108:154244 View Article PubMed/NCBI
  6. Gao F, Zheng KI, Wang XB, Yan HD, Sun QF, Pan KH, et al. Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients. J Gastroenterol Hepatol 2020;36(1):204-207 View Article PubMed/NCBI
  7. Targher G, Mantovani A, Byrne CD, Wang XB, Yan HD, Sun QF, et al. Risk of severe illness from COVID-19 in patients with metabolic dysfunction-associated fatty liver disease and increased fibrosis scores. Gut 2020;69(8):1545-1547 View Article PubMed/NCBI
  8. Walsh EE, Frenck RW, Falsey AR, Kitchin N, Absalon J, Gurtman A, et al. Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates. N Engl J Med 2020;383(25):2439-2450 View Article PubMed/NCBI
  9. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020;367(6483):1260-1263 View Article PubMed/NCBI
  10. Pfizer pharmaceutical company. Comirnaty (BioNTech). U.S. Food and Drug Administration. Available from: https://www.fda.gov/media/151707/download
  11. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med 2020;383(27):2603-2615 View Article PubMed/NCBI
  12. Thomas SJ, Moreira ED, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months. N Engl J Med 2021;385(19):1761-1773 View Article PubMed/NCBI
  13. Moreira ED, Kitchin N, Xu X, Dychter SS, Lockhart S, Gurtman A, et al. Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine. N Engl J Med 2022;386(2):1910-1921 View Article PubMed/NCBI
  14. Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, et al. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature 2020;586(7830):567-571 View Article PubMed/NCBI
  15. Moderna, Inc pharmaceutical company. Spikevax (COVID-19 Vaccine, mRNA). U.S. Food and Drug Administration. Available from: https://www.fda.gov/media/155675/download
  16. Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med 2021;384(5):403-416 View Article PubMed/NCBI
  17. John BV, Deng Y, Scheinberg A, Mahmud N, Taddei TH, Kaplan D, et al. Association of BNT162b2 mRNA and mRNA-1273 Vaccines With COVID-19 Infection and Hospitalization Among Patients With Cirrhosis. JAMA Intern Med 2021;181(10):1306-1314 View Article PubMed/NCBI
  18. John BV, Deng Y, Schwartz KB, Taddei TH, Kaplan DE, Martin P, et al. Postvaccination COVID-19 infection is associated with reduced mortality in patients with cirrhosis. Hepatology 2022;76:126-138 View Article PubMed/NCBI
  19. Bakasis AD, Bitzogli K, Mouziouras D, Pouliakis A, Roumpoutsou M, Goules AV, et al. Antibody Responses after SARS-CoV-2 Vaccination in Patients with Liver Diseases. Viruses 2022;14(2):207 View Article PubMed/NCBI
  20. Thuluvath PJ, Robarts P, Chauhan M. Analysis of antibody responses after COVID-19 vaccination in liver transplant recipients and those with chronic liver diseases. J Hepatol 2021;75(6):1434-1439 View Article PubMed/NCBI
  21. Ruether DF, Schaub GM, Duengelhoef PM, Haag F, Brehm TT, Fathi A, et al. SARS-CoV2-specific Humoral and T-cell Immune Response After Second Vaccination in Liver Cirrhosis and Transplant Patients. Clin Gastroenterol Hepatol 2022;20(1):162-172.e9 View Article PubMed/NCBI
  22. Shafrir A, Amer J, Hakimian D, Milgrom Y, Massarwa M, Hazou W, et al. Advanced Liver Fibrosis Correlates With Impaired Efficacy of Pfizer-BioNTech COVID-19 Vaccine in Medical Employees. Hepatol Commun 2022;6(6):1278-1288 View Article PubMed/NCBI
  23. Strauss AT, Hallett AM, Boyarsky BJ, Ou MT, Werbel WA, Avery RK, et al. Antibody Response to Severe Acute Respiratory Syndrome-Coronavirus-2 Messenger RNA Vaccines in Liver Transplant Recipients. Liver Transpl 2021;27(12):1852-1856 View Article PubMed/NCBI
  24. Rabinowich L, Grupper A, Baruch R, Ben-Yehoyada M, Halperin T, Turner D, et al. Low immunogenicity to SARS-CoV-2 vaccination among liver transplant recipients. J Hepatol 2021;75(2):435-438 View Article PubMed/NCBI
  25. Huang HJ, Yi SG, Mobley CM, Saharia A, Bhimaraj A, Moore LW, et al. Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients. Clin Transplant 2022;36(5):e14600 View Article PubMed/NCBI
  26. Toniutto P, Falleti E, Cmet S, Cussigh A, Veneto L, Bitetto D, et al. Past COVID-19 and immunosuppressive regimens affect the long-term response to anti-SARS-CoV-2 vaccination in liver transplant recipients. J Hepatol 2022;77(1):152-162 View Article PubMed/NCBI
  27. Davidov Y, Tsaraf K, Cohen-Ezra O, Likhter M, Ben Yakov G, Levy I, et al. Immunogenicity and Adverse Effects of the 2-Dose BNT162b2 Messenger RNA Vaccine Among Liver Transplantation Recipients. Liver Transpl 2022;28(2):215-223 View Article PubMed/NCBI
  28. Herrera S, Colmenero J, Pascal M, Escobedo M, Castel MA, Sole-González E, et al. Cellular and humoral immune response after mRNA-1273 SARS-CoV-2 vaccine in liver and heart transplant recipients. Am J Transplant 2021;21(12):3971-3979 View Article PubMed/NCBI
  29. Fernández-Ruiz M, Almendro-Vázquez P, Carretero O, Ruiz-Merlo T, Laguna-Goya R, San Juan R, et al. Discordance Between SARS-CoV-2-specific Cell-mediated and Antibody Responses Elicited by mRNA-1273 Vaccine in Kidney and Liver Transplant Recipients. Transplant Direct 2021;7(12):e794 View Article PubMed/NCBI
  30. Rahav G, Lustig Y, Lavee J, Benjamini O, Magen H, Hod T, et al. BNT162b2 mRNA COVID-19 vaccination in immunocompromised patients: A prospective cohort study. EClinicalMedicine 2021;41:101158 View Article PubMed/NCBI
  31. Nazaruk P, Monticolo M, Jędrzejczak AM, Krata N, Moszczuk B, Sańko-Resmer J, et al. Unexpectedly High Efficacy of SARS-CoV-2 BNT162b2 Vaccine in Liver versus Kidney Transplant Recipients-Is It Related to Immunosuppression Only?. Vaccines (Basel) 2021;9(12):1454 View Article PubMed/NCBI
  32. Boyarsky BJ, Werbel WA, Avery RK, Tobian AAR, Massie AB, Segev DL, et al. Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients. JAMA 2021;325(21):2204-2206 View Article PubMed/NCBI
  33. Ai J, Wang J, Liu D, Xiang H, Guo Y, Lv J, et al. Safety and Immunogenicity of SARS-CoV-2 Vaccines in Patients With Chronic Liver Diseases (CHESS-NMCID 2101): A Multicenter Study. Clin Gastroenterol Hepatol 2022;20(7):1516-1524.e2 View Article PubMed/NCBI
  34. He T, Zhou Y, Xu P, Ling N, Chen M, Huang T, et al. Safety and antibody response to inactivated COVID-19 vaccine in patients with chronic hepatitis B virus infection. Liver Int 2022;42(6):1287-1296 View Article PubMed/NCBI
  35. Xiang T, Liang B, Wang H, Quan X, He S, Zhou H, et al. Safety and immunogenicity of a SARS-CoV-2 inactivated vaccine in patients with chronic hepatitis B virus infection. Cell Mol Immunol 2021;18(12):2679-2681 View Article PubMed/NCBI
  36. Wang J, Hou Z, Liu J, Gu Y, Wu Y, Chen Z, et al. Safety and immunogenicity of COVID-19 vaccination in patients with non-alcoholic fatty liver disease (CHESS2101): A multicenter study. J Hepatol 2021;75(2):439-441 View Article PubMed/NCBI
  37. Rhee Y, Sha BE, Santos CAQ. Optimizing Vaccination in Adult Patients With Liver Disease and Liver Transplantation. Clin Liver Dis (Hoboken) 2020;15(2):63-68 View Article PubMed/NCBI
  38. European Association for Study of Liver; Asociacion Latinoamericana para el Estudio del Higado. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol 2015;63(1):237-264 View Article PubMed/NCBI
  39. Mungmunpuntipantip R, Wiwanitkit V. Coronavirus Disease 2019 Messenger RNA Vaccine and Liver Transplant Recipients. Liver Transpl 2022;28(1):140 View Article PubMed/NCBI
  40. Klein NP, Lewis N, Goddard K, Fireman B, Zerbo O, Hanson KE, et al. Surveillance for Adverse Events After COVID-19 mRNA Vaccination. JAMA 2021;326(14):1390-1399 View Article PubMed/NCBI
  41. Meo SA, Bukhari IA, Akram J, Meo AS, Klonoff DC. COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. Eur Rev Med Pharmacol Sci 2021;25(3):1663-1669 View Article PubMed/NCBI
  42. Alqarni MM, Faloudah AZ, Alsulaihebi AS, Halawani HK, Khan AS. A Case of Hepatotoxicity After Receiving a COVID-19 Vaccine. Cureus 2021;13(12):e20455 View Article PubMed/NCBI
  43. Dumortier J. Liver injury after mRNA-based SARS-CoV-2 vaccination in a liver transplant recipient. Clin Res Hepatol Gastroenterol 2022;46(1):101743 View Article PubMed/NCBI
  44. Shroff H, Satapathy SK, Crawford JM, Todd NJ, VanWagner LB. Liver injury following SARS-CoV-2 vaccination: A multicenter case series. J Hepatol 2022;76(1):211-214 View Article PubMed/NCBI
  45. Lodato F, Larocca A, D’Errico A, Cennamo V. An unusual case of acute cholestatic hepatitis after m-RNABNT162b2 (Comirnaty) SARS-CoV-2 vaccine: Coincidence, autoimmunity or drug-related liver injury. J Hepatol 2021;75(5):1254-1256 View Article PubMed/NCBI
  46. Bril F, Al Diffalha S, Dean M, Fettig DM. Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: Causality or casualty?. J Hepatol 2021;75(1):222-224 View Article PubMed/NCBI
  47. Avci E, Abasiyanik F. Autoimmune hepatitis after SARS-CoV-2 vaccine: New-onset or flare-up?. J Autoimmun 2021;125:102745 View Article PubMed/NCBI
  48. Palla P, Vergadis C, Sakellariou S, Androutsakos T. Letter to the editor: Autoimmune hepatitis after COVID-19 vaccination: A rare adverse effect?. Hepatology 2022;75(2):489-490 View Article PubMed/NCBI
  49. Rocco A, Sgamato C, Compare D, Nardone G. Autoimmune hepatitis following SARS-CoV-2 vaccine: May not be a casuality. J Hepatol 2021;75(3):728-729 View Article PubMed/NCBI
  50. Garrido I, Lopes S, Simões MS, Liberal R, Lopes J, Carneiro F, et al. Autoimmune hepatitis after COVID-19 vaccine - more than a coincidence. J Autoimmun 2021;125:102741 View Article PubMed/NCBI
  51. Vuille-Lessard É, Montani M, Bosch J, Semmo N. Autoimmune hepatitis triggered by SARS-CoV-2 vaccination. J Autoimmun 2021;123:102710 View Article PubMed/NCBI
  52. Ghielmetti M, Schaufelberger HD, Mieli-Vergani G, Cerny A, Dayer E, Vergani D, et al. Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: A novel clinical entity?. J Autoimmun 2021;123:102706 View Article PubMed/NCBI
  53. Tan CK, Wong YJ, Wang LM, Ang TL, Kumar R. Autoimmune hepatitis following COVID-19 vaccination: True causality or mere association?. J Hepatol 2021;75(5):1250-1252 View Article PubMed/NCBI
  54. Zin Tun GS, Gleeson D, Al-Joudeh A, Dube A. Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed. J Hepatol 2022;76(3):747-749 View Article PubMed/NCBI
  55. McShane C, Kiat C, Rigby J, Crosbie Ó. The mRNA COVID-19 vaccine - A rare trigger of autoimmune hepatitis?. J Hepatol 2021;75(5):1252-1254 View Article PubMed/NCBI
  56. Londoño MC, Gratacós-Ginès J, Sáez-Peñataro J. Another case of autoimmune hepatitis after SARS-CoV-2 vaccination - still casualty?. J Hepatol 2021;75(5):1248-1249 View Article PubMed/NCBI
  57. Clayton-Chubb D, Schneider D, Freeman E, Kemp W, Roberts SK. Autoimmune hepatitis developing after the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccine. J Hepatol 2021;75(5):1249-1250 View Article PubMed/NCBI
  58. Rela M, Jothimani D, Vij M, Rajakumar A, Rammohan A. Auto-immune hepatitis following COVID vaccination. J Autoimmun 2021;123:102688 View Article PubMed/NCBI
  59. Ghorbani H, Rouhi T, Vosough Z, Shokri-Shirvani J. Drug-induced hepatitis after Sinopharm COVID-19 vaccination: A case study of a 62-year-old patient. Int J Surg Case Rep 2022;93:106926 View Article PubMed/NCBI
  60. Vojdani A, Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin Immunol 2020;217:108480 View Article PubMed/NCBI
  61. Segal Y, Shoenfeld Y. Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction. Cell Mol Immunol 2018;15(6):586-594 View Article PubMed/NCBI
  62. Talotta R. Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply to “potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases”. Clin Immunol 2021;224:108665 View Article PubMed/NCBI
  63. Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, et al. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet 2021;397(10269):99-111 View Article PubMed/NCBI
  64. Falsey AR, Sobieszczyk ME, Hirsch I, Sproule S, Robb ML, Corey L, et al. Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine. N Engl J Med 2021;385(25):2348-2360 View Article PubMed/NCBI
  65. Munro APS, Janani L, Cornelius V, Aley PK, Babbage G, Baxter D, et al. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV -BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial. Lancet 2021;398(10318):2258-2276 View Article PubMed/NCBI
  66. Flaxman A, Marchevsky NG, Jenkin D, Aboagye J, Aley PK, Angus B, et al. Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002). Lancet 2021;398(10304):981-990 View Article PubMed/NCBI
  67. Pavord S, Scully M, Hunt BJ, Lester W, Bagot C, Craven B, et al. Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis. N Engl J Med 2021;385(18):1680-1689 View Article PubMed/NCBI
  68. Scully M, Singh D, Lown R, Poles A, Solomon T, Levi M, et al. Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021;384(23):2202-2211 View Article PubMed/NCBI
  69. Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. N Engl J Med 2021;384(22):2092-2101 View Article PubMed/NCBI
  70. Bourguignon A, Arnold DM, Warkentin TE, Smith JW, Pannu T, Shrum JM, et al. Adjunct Immune Globulin for Vaccine-Induced Immune Thrombotic Thrombocytopenia. N Engl J Med 2021;385(8):720-728 View Article PubMed/NCBI
  71. Bos R, Rutten L, van der Lubbe JEM, Bakkers MJG, Hardenberg G, Wegmann F, et al. Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 spike immunogen induces potent humoral and cellular immune responses. NPJ Vaccines 2020;5:91 View Article PubMed/NCBI
  72. Sadoff J, Le Gars M, Shukarev G, Heerwegh D, Truyers C, de Groot AM, et al. Interim results of a phase 1–2a trial of Ad26.COV2.S Covid-19 vaccine. N Engl J Med 2021;384(19):1824-1835 View Article PubMed/NCBI
  73. Sadoff J, Gray G, Vandebosch A, Cárdenas V, Shukarev G, Grinsztejn B, et al. Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19. N Engl J Med 2021;384(23):2187-2201 View Article PubMed/NCBI
  74. Awadasseid A, Wu Y, Tanaka Y, Zhang W. Current advances in the development of SARS-CoV-2 vaccines. Int J Biol Sci 2021;17(1):8-19 View Article PubMed/NCBI
  75. Tanriover MD, Doğanay HL, Akova M, Güner HR, Azap A, Akhan S, et al. Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey. Lancet 2021;398(10296):213-222 View Article PubMed/NCBI
  76. Ella R, Reddy S, Blackwelder W, Potdar V, Yadav P, Sarangi V, et al. Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial. Lancet 2021;398(10317):2173-2184 View Article PubMed/NCBI
  77. Al Kaabi N, Zhang Y, Xia S, Yang Y, Al Qahtani MM, Abdulrazzaq N, et al. Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: A Randomized Clinical Trial. JAMA 2021;326(1):35-45 View Article PubMed/NCBI
  78. Bueno SM, Abarca K, González PA, Gálvez NM, Soto JA, Duarte LF, et al. Interim report: Safety and immunogenicity of an inactivated vaccine against SARS-CoV-2 in healthy chilean adults in a phase 3 clinical trial. medRxiv 2021 View Article PubMed/NCBI
  79. Yorsaeng R, Suntronwong N, Phowatthanasathian H, Assawakosri S, Kanokudom S, Thongmee T, et al. Immunogenicity of a third dose viral-vectored COVID-19 vaccine after receiving two-dose inactivated vaccines in healthy adults. Vaccine 2022;40(3):524-530 View Article PubMed/NCBI
  80. Zhang J, He Q, An C, Mao Q, Gao F, Bian L, et al. Boosting with heterologous vaccines effectively improves protective immune responses of the inactivated SARS-CoV-2 vaccine. Emerg Microbes Infect 2021;10(1):1598-1608 View Article PubMed/NCBI
  81. Yue L, Zhou J, Zhou Y, Yang X, Xie T, Yang M, et al. Antibody response elicited by a third boost dose of inactivated SARS-CoV-2 vaccine can neutralize SARS-CoV-2 variants of concern. Emerg Microbes Infect 2021;10(1):2125-2127 View Article PubMed/NCBI
  82. Yue L, Xie T, Yang T, Zhou J, Chen H, Zhu H, et al. A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS-CoV-2 vaccine. J Med Virol 2022;94(1):35-38 View Article PubMed/NCBI
  83. Ai J, Zhang H, Zhang Y, Lin K, Zhang Y, Wu J, et al. Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost. Emerg Microbes Infect 2022;11(1):337-343 View Article PubMed/NCBI
  84. Zeng G, Wu Q, Pan H, Li M, Yang J, Wang L, et al. Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials. Lancet Infect Dis 2022;22(4):483-495 View Article PubMed/NCBI
  85. Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, et al. Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus. Immunity 2018;49:725-739.e6 View Article PubMed/NCBI
  86. Charles ED, Brunetti C, Marukian S, Ritola KD, Talal AH, Marks K, et al. Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset. Blood 2011;117:5425-5437 View Article PubMed/NCBI
  87. Liu N, Liu B, Zhang L, Li H, Chen Z, Luo A, et al. Recovery of circulating CD56(dim) NK cells and the balance of Th17/Treg after nucleoside analog therapy in patients with chronic hepatitis B and low levels of HBsAg. Int Immunopharmacol 2018;62:59-66 View Article PubMed/NCBI
  88. Murata K, Asano M, Matsumoto A, Sugiyama M, Nishida N, Tanaka E, et al. Induction of IFN-lambda3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection. Gut 2018;67(2):362-371 View Article PubMed/NCBI
  89. Keech C, Albert G, Cho I, Robertson A, Reed P, Neal S, et al. Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine. N Engl J Med 2020;383(24):2320-2332 View Article PubMed/NCBI
  90. Parums DV. Editorial: First Approval of the Protein-Based Adjuvanted Nuvaxovid (NVX-CoV2373) Novavax Vaccine for SARS-CoV-2 Could Increase Vaccine Uptake and Provide Immune Protection from Viral Variants. Med Sci Monit 2022;28:e936523 View Article PubMed/NCBI
  91. Formica N, Mallory R, Albert G, Robinson M, Plested JS, Cho I, et al. Different dose regimens of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373) in younger and older adults: A phase 2 randomized placebo-controlled trial. PLoS Med 2021;18(10):e1003769 View Article PubMed/NCBI
  92. Heath PT, Galiza EP, Baxter DN, Boffito M, Browne D, Burns F, et al. Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine. N Engl J Med 2021;385(13):1172-1183 View Article PubMed/NCBI
  93. Dunkle LM, Kotloff KL, Gay CL, Áñez G, Adelglass JM, Barrat Hernández AQ, et al. Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico. N Engl J Med 2022;386(6):531-543 View Article PubMed/NCBI
  94. Shinde V, Bhikha S, Hoosain Z, Archary M, Bhorat Q, Fairlie L, et al. Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant. N Engl J Med 2021;384(20):1899-1909 View Article PubMed/NCBI
  95. Montastruc JL, Biron P, Sommet A. NVX-Cov2373 Novavax Covid-19 vaccine: A further analysis of its efficacy using multiple modes of expression. Fundam Clin Pharmacol 2022;36(6):1125-1127 View Article PubMed/NCBI
  96. Madhi SA, Moodley D, Hanley S, Archary M, Hoosain Z, Lalloo U, et al. Immunogenicity and safety of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine in people living with and without HIV-1 infection: a randomised, controlled, phase 2A/2B trial. Lancet HIV 2022;9(5):e309-e322 View Article PubMed/NCBI
  97. Andrews N, Stowe J, Kirsebom F, Toffa S, Rickeard T, Gallagher E, et al. Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant. N Engl J Med 2022;386(16):1532-1546 View Article PubMed/NCBI
  98. Regev-Yochay G, Gonen T, Gilboa M, Mandelboim M, Indenbaum V, Amit S, et al. Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron. N Engl J Med 2022;386(14):1377-1380 View Article PubMed/NCBI
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  • Journal of Clinical and Translational Hepatology
  • pISSN 2225-0719
  • eISSN 2310-8819

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Efficacy of Vaccine Protection Against COVID-19 Virus Infection in Patients with Chronic Liver Diseases

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