Drugs are used to prevent, diagnose, and treat diseases, as well as improve physiological function and health level. With the increasing number of drug types and the lack of formal drug methods, the incidence of adverse reactions to drugs is also rising. Drug-induced liver disease is so common that in addition to poor drug quality, irrational drug use is the main reason, including drug abuse, misuse, low medical quality, and knowledge level of patients and their families; in addition, social problems such as lack of scientific management, medical ethics, and medical staff. Therefore, it is imperative to strengthen drug management, improve drug safety, and reduce the incidence of adverse reactions. Here we it is introduce and elaborate the current situation and progress in the diagnosis of drug-induced liver disease in recent years, so as to build a learning platform for the prevention and treatment of drug-induced liver disease in China.