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Online First Articles

The online first articles are peer reviewed, accepted, and are ready for publication, with copyediting, typesetting, proofreading and author review. They have not been assigned to a journal issue; an article will be removed from this page once it is published in a coming issue.

Articles published online first are citable. To cite an article on this page, please refer to the following example:

Yi SG, Sadhu AR, Jones SL, Turner K, Monsour H, Donahue K, et al. The Effect of Adrenal Replacement Therapy on Rates of Fungal Colonization and Mortality in Critically Ill Patients Awaiting Liver Transplantation. J Clin Transl Hepatol. Published online: Sep 15, 2013. doi: 10.14218/JCTH.2013.00007.

Original Article

Metabolic Liver Diseases

Integrative Multi-omics and Machine Learning Reveal the Therapeutic Mechanisms of Juanyu-Xiaozhi Formula in Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatic Fibrosis via the AP-1/PPARγ/SCD1 Axis

Zhiqiang Jin, Yi Huang, Cheng Zeng, Yueting Zhang, Yu Qiu, Yang Yang, Huabao Liu

Published online: August 7, 2026

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doi:10.14218/JCTH.2026.00106

Comparative Efficacy of Promising Targets in the Treatment of Metabolic Dysfunction-associated Steatotic Liver Disease and Steatohepatitis: A Systematic Review and Network Meta-analysis

Wenjing Ni, Jie Li, Xue Bai, Sisi Zhou, Xiangyu Wu, Leyao Jia, Zhuoru Jiang, Jiali Wu, Ming Li, Connie Wong, Chao Wu, Junping Shi, Mindie H. Nguyen

Published online: July 20, 2026

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doi:10.14218/JCTH.2025.00596

Liver Injury, Autoimmune, and Cholestatic Diseases

Early Prediction of Non-recovery in Drug-induced Liver Injury by Integrating Genetic Variants and Clinical Variables: An Interpretable Machine Learning Approach

Jingjing Jiang, Weiwei Lou, Qing Li, Ziqiang Li, Weiqian Lou, Xichen Zhu, Qing Xie, Rongtao Lai

Published online: August 5, 2026

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doi:10.14218/JCTH.2026.00447

Berberine Attenuates Hepatic Sinusoidal Obstruction Syndrome by Inhibiting Endothelial-mediated Neutrophil Recruitment and Activation

Yiken Lin, Wenjia Tian, Weiming Dai, Ning Chen, Huifeng Hao, Yulan Liu

Published online: July 20, 2026

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doi:10.14218/JCTH.2026.00024

Infectious Hepatitis

Comparison of Peg-INF plus TDF versus TDF Monotherapy in Indeterminate-phase Chronic Hepatitis B Patients with High HBsAg levels, HBeAg-negative status, and Normal ALT Levels

Min Liu, An Xiao, Bing Bu, Lili Zuo, Yuting Zhang, Ling Zhu, Liping Huang, Yilan Wang, Jinbo Luo, Wei Yue, Jiawei Geng

Published online: August 4, 2026

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doi:10.14218/JCTH.2026.00015

Liver Failure, Cirrhosis and Portal Hypertension

Plasma Metabolites for Identifying Bacterial Infection in Acute-on-chronic Liver Failure: A Prospective Multicenter Study

Xiaotian Yang, Hai Li, Yan Huang, Guohong Deng, Beiling Li, Xianbo Wang, Zhongji Meng, Yubao Zheng, Yanhang Gao, Zhiping Qian, Feng Liu, Xiaobo Lu, Yu Shi, Jia Shang, Jing Liu, Hang Jia, Sumeng Li, Lining Guo, Xin Zheng

Published online: August 3, 2026

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doi:10.14218/JCTH.2026.00384

Review Article

Molecular Basis and Clinical Significance of the High-risk Phenotype of Hepatitis B Virus Genotype C

Chenchen Huang, Zhongjian Liu, Jingyao Zhang, Tao Shen, Lei Sang

Published online: July 27, 2026

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doi:10.14218/JCTH.2026.00247

Research Letter

qHBsAg Trajectories with Peg-IFNα-2b Add-on Therapy in Nucleos(t)ide Analog-experienced HBeAg-positive Chronic Hepatitis B

Kezhen Hu, Yanzhen Bi, Xiaoying Li, Xiangzhong Liu, Haoxi Wang, Yong Zhou, Yongning Xin

Published online: July 24, 2026

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doi:10.14218/JCTH.2026.00175